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Seizure‐onset regions demonstrate high inward directed connectivity during resting‐state: An SEEG study in focal epilepsy
Epilepsia ( IF 5.6 ) Pub Date : 2020-09-18 , DOI: 10.1111/epi.16686
Saramati Narasimhan 1, 2, 3 , Keshav B Kundassery 2 , Kanupriya Gupta 1, 2 , Graham W Johnson 2, 3 , Kristin E Wills 1, 2 , Sarah E Goodale 2, 3 , Kevin Haas 4 , John D Rolston 5 , Robert P Naftel 1 , Victoria L Morgan 1, 2, 3, 6 , Benoit M Dawant 3, 7 , Hernán F J González 2, 3 , Dario J Englot 1, 2, 3, 6, 7
Affiliation  

In patients with medically refractory focal epilepsy, stereotactic‐electroencephalography (SEEG) can aid in localizing epileptogenic regions for surgical treatment. SEEG, however, requires long hospitalizations to record seizures, and ictal interpretation can be incomplete or inaccurate. Our recent work showed that non‐directed resting‐state analyses may identify brain regions as epileptogenic or uninvolved. Our present objective is to map epileptogenic networks in greater detail and more accurately identify seizure‐onset regions using directed resting‐state SEEG connectivity.

中文翻译:

癫痫发作区域在静息状态下表现出高度的内向连通性:局灶性癫痫的 SEEG 研究

对于药物难治性局灶性癫痫患者,立体定向脑电图 (SEEG) 可以帮助定位致癫痫区域以进行手术治疗。然而,SEEG 需要长时间住院来记录癫痫发作,并且发作期解释可能不完整或不准确。我们最近的工作表明,非定向静息状态分析可以将大脑区域识别为致癫痫或未受累的大脑区域。我们目前的目标是更详细地绘制致癫痫网络,并使用定向静息状态 SEEG 连接更准确地识别癫痫发作区域。
更新日期:2020-09-18
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