Pyrido[2,3‐d]pyrimidine, a fused hetero‐bicyclic nucleus containing pyridine and pyrimidine rings has attained the momentary attention in the sphere of multicomponent synthetic protocol and medicinal chemist. Pyrido[2,3‐d]pyrimidine derived drugs have manifested diverse pharmacological activities, particularly, anti‐inflammatory, cytotoxic, antimicrobial, phosphodiesterase inhibitors and cytokine inhibitors etc. The present review illustrates various modern synthetic strategies adopted, the structure–activity relationship (SAR) aspects and discloses the extensive crucial biological properties (anticancer, anti‐infectious, anti‐diabetics and CNS agents) of pyrido[2,3‐d]pyrimidines.

中文翻译：

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吡啶并[2,3-d]嘧啶支架的合成和药物前景概述

吡啶并[2,3- d ]嘧啶是一种含有吡啶和嘧啶环的稠合杂双环核，在多组分合成方案和药物化学家领域引起了短暂的关注。吡啶并[2,3- d ]嘧啶衍生药物具有多种药理活性，特别是抗炎、细胞毒、抗菌、磷酸二酯酶抑制剂和细胞因子抑制剂等。本综述阐述了采用的各种现代合成策略、构效关系（ SAR）方面并公开了吡啶并[2,3- d ]嘧啶广泛的关键生物学特性（抗癌、抗感染、抗糖尿病和中枢神经系统药物）。