We report that atomically thin two-dimensional silicon quantum sheets (2D Si QSs), prepared by a scalable approach coupling chemical delithiation and cryo-assisted exfoliation, can serve as a high-performance brain photonic nanoagent for orthotopic glioma theranostics. With the lateral size of approximately 14.0 nm and thickness of about 1.6 nm, tiny Si QSs possess high mass extinction coefficient of 27.5 L g⁻¹ cm⁻¹ and photothermal conversion efficiency of 47.2% at 808 nm, respectively, concurrently contributing to the best photothermal performance among the reported 2D mono-elemental materials (Xenes). More importantly, Si QSs with low toxicity maintain the trade-off between stability and degradability, paving the way for practical clinical translation in consideration of both storage and action of nanoagents. In vitro Transwell filter experiment reveals that Si QSs could effectively go across the bEnd.3 cells monolayer. Upon the intravenous injection of Si QSs, orthotopic brain tumors are effectively inhibited under the precise guidance of photoacoustic imaging, and the survival lifetime of brain tumor-bearing mice is increased by two fold. Atomically thin Si QSs with strong light-harvesting capability are expected to provide an effective and robust 2D photonic nanoplatform for the management of brain diseases.

我们报告说，原子级薄的二维硅量子片 (2D Si QSs)，通过可扩展的方法结合化学脱锂和低温辅助剥离制备，可以作为用于原位神经胶质瘤治疗的高性能脑光子纳米剂。^{横向尺寸约为 14.0 nm，厚度约为 1.6 nm，微小的 Si QS 具有 27.5 L g −1} cm ⁻¹的高质量消光系数和 808 nm 处的光热转换效率分别为 47.2%，同时在已报道的二维单元素材料 (Xenes) 中贡献了最佳的光热性能。更重要的是，低毒性的 Si QSs 保持了稳定性和可降解性之间的平衡，为考虑到纳米制剂的储存和作用的实际临床转化铺平了道路。体外Transwell 过滤实验表明 Si QS 可以有效地穿过 bEnd.3 细胞单层。静脉注射Si QSs后，原位脑肿瘤在光声成像的精确引导下得到有效抑制，荷瘤小鼠的生存寿命提高了两倍。具有强大光捕获能力的原子级薄 Si QS 有望为脑部疾病的管理提供有效且稳健的二维光子纳米平台。