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The strategies and techniques of drug discovery from natural products.
Pharmacology & Therapeutics ( IF 13.5 ) Pub Date : 2020-09-19 , DOI: 10.1016/j.pharmthera.2020.107686
Li Zhang 1 , Junke Song 2 , Linglei Kong 2 , Tianyi Yuan 2 , Wan Li 2 , Wen Zhang 2 , Biyu Hou 2 , Yang Lu 3 , Guanhua Du 2
Affiliation  

Natural products have been the main sources of new drugs. The different strategies have been developed to find the new drugs based on natural products. The traditional and ethic medicines have provided information on the therapeutic effects and resulted in some notable drug discovery of natural products. The special activities of the medicine plants such as the side effects have inspired scientists to develop the novel small molecular. The microorganisms and the endogenous active substances from human or animal also become the important approaches to the drug discovery. The tremendous progress in technology led to the new strategies in drug discovery from natural products. The bioinformation and artificial intelligence have facilitated the research and development of natural products. We will provide a scene of strategies and technologies for drug discovery from natural products in this review.



中文翻译:

从天然产物中发现药物的策略和技术。

天然产物一直是新药的主要来源。已经开发了不同的策略来寻找基于天然产物的新药。传统和伦理药物提供了有关治疗效果的信息,并导致了一些显着的天然产物药物发现。药用植物的副作用等特殊活性激发了科学家们开发新型小分子的灵感。来自人或动物的微生物和内源性活性物质也成为药物发现的重要途径。技术的巨大进步导致了从天然产物中发现药物的新策略。生物信息和人工智能促进了天然产物的研究和开发。

更新日期:2020-11-21
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