There is an urgent clinical for small diameter vascular grafts (SDVGs) for use in the treatment of coronary artery disease. Moreover, biodegradable SDVGs are drawing increasing attention because they have the potential to restore vascular function with the degradation of vascular graft and tissue regeneration. In this study, we designed triple-layered SDVGs to mimic the native arterial structure, with each layer contributing its unique porosity to the porous structure. We evaluated triple-layered SDVGs in a sheep carotid arterial replacement model. After implantation for 12 months, two grafts were patent and indicated the feasibility of using grafts in large animals. Nevertheless, it was determined that both grafts formed aneurysms at the proximal end. The prevention of such aneurysms remains a challenge for future investigation.

临床上迫切需要使用小直径血管移植物 (SDVG) 来治疗冠状动脉疾病。此外，可生物降解的 SDVG 正引起越来越多的关注，因为它们有可能通过血管移植物的降解和组织再生来恢复血管功能。在这项研究中，我们设计了三层 SDVG 来模拟天然动脉结构，每一层都为多孔结构贡献其独特的孔隙率。我们在绵羊颈动脉置换模型中评估了三层 SDVG。植入 12 个月后，两个移植物获得专利并表明在大型动物中使用移植物的可行性。尽管如此，确定两个移植物都在近端形成了动脉瘤。预防此类动脉瘤仍然是未来调查的挑战。