Theranostic ions offer suitable platforms for cancer theranostics; here, the effect of doping various amounts of theranostic ions (i.e., Sr²⁺, Fe²⁺, and Ti⁴⁺ ions) on the physicochemical properties and biological activities of calcium phosphates (CaPs) were investigated. The solution combustion synthesis (SCS) was conducted at different amounts of ions (i.e., = 0.1, 0.25, 0.5 mole). Desirable physicochemical properties were obtained in doped samples with 0.1 mole of ions. The particle size of the Sr, Fe, and Ti-doped samples was decreased from 68 to 39, 24, and 29 nm, respectively. The surface charge of the mentioned samples was changed from -20 to -24, -28, and -25 mV, respectively. Besides, the specific surface area of the mentioned samples was significantly increased from 38 to 79, 65, and 106 m²/g, respectively. It was found that bioactivity of doped CaPs improved ~ 95%, which relied on the high adsorption and desorption rate of Ca²⁺ ions in the simulated body fluid (SBF). The in vitro cell-based results demonstrate the potent effect of CaPs and theranostic ions doped CaPs on the reactive oxygen species (ROS) generation. In the presence of CaPs, the intracellular ROS generation is increased by about 60%. Besides, the intracellular ROS generation is improved in Sr²⁺, Fe²⁺, and Ti⁴⁺ ions doped CaPs by about 66, 64, and 68%. As a result of the high generation of ROS, the bone nodule formation of cell treated CaPs and theranostic ions doped CaPs is improved 25%-37%. Finally, it can be concluded that the use of the SCS approaches for doping of theranostic ions causes well-physicochemical properties and high biological activities.

Theranostic离子提供了适合癌症癌症治疗的平台。在这里，掺杂各种数量的检定离子（即Sr 2 ⁺，Fe ²⁺和Ti ⁴⁺离子）对磷酸钙（CaPs）的理化性质和生物活性的研究。固溶燃烧合成（SCS）是在不同数量的离子（即= 0.1、0.25、0.5摩尔）下进行的。在具有0.1摩尔离子的掺杂样品中获得了理想的理化特性。掺Sr，Fe和Ti的样品的粒径分别从68 nm减小到39、24和29 nm。所述样品的表面电荷分别从-20变为-24，-28和-25 mV。此外，所述样品的比表面积分别从38增加到79、65和106m ² / g。发现掺杂的CaPs的生物活性提高了约95％，这取决于Ca ²⁺的高吸附和解吸速率模拟体液（SBF）中的离子。在体外基于细胞的结果证明瓶盖和治疗诊断离子的有效的作用掺杂上的反应性氧物质（ROS）的产生上限。在CaPs的存在下，细胞内ROS的产生增加了约60％。此外，Sr 2 ⁺，Fe ²⁺和Ti ⁴⁺离子掺杂的CaPs的细胞内ROS生成分别提高了66％，64％和68％。由于产生了大量的ROS，细胞处理过的CaPs和经脉络膜离子掺杂的CaPs的结节形成得以改善25％-37％。最后，可以得出结论，使用SCS方法掺杂金属离子，会导致良好的物理化学性质和高生物活性。