Organic-inorganic composite hydrogel materials have been widely studied. In order to expand the application of organic-inorganic composite hydrogel materials, in this work, we prepared a viscous hydrogel with antibacterial properties (OSA-GelDA@ACP/DA/Ag). First, we used polydopamine coating to deposit elemental silver on the surface of amorphous calcium phosphate (ACP) particles to prepare ACP/DA/Ag particles. Next, dopamine was grafted on the gelatin molecular chain by EDC/NHS to activate the carboxyl group to obtain dopamine-modified gelatin (GelDA). The content of DA in GelDA is about 14.09% by standard curve method. Then, the Schiff base reaction took place between the amino group on the GelDA molecular chain and the aldehyde group on the OSA molecular chain, and an OSA-GelDA viscous hydrogel was prepared. Finally, by changing the content of ACP/DA/Ag3 particles added to the OSA-GelDA gel, the corresponding performance of material was investigated. The results show that the introduction of dopamine provides wet viscosity for the hydrogel, and the ACP/DA/Ag3 particles introduced in the viscous hydrogel provide antibacterial properties. This hydrogel with antibacterial and wet viscosity is expected to become an injectable bone repair material for clinical use.

有机-无机复合水凝胶材料已被广泛研究。为了扩大有机-无机复合水凝胶材料的应用，在这项工作中，我们制备了具有抗菌特性的粘性水凝胶（OSA-GelDA @ ACP / DA / Ag）。首先，我们使用聚多巴胺涂层在无定形磷酸钙（ACP）颗粒表面沉积元素银，以制备ACP / DA / Ag颗粒。接下来，通过EDC / NHS将多巴胺接枝到明胶分子链上以活化羧基以获得多巴胺修饰的明胶（GelDA）。通过标准曲线法，GelDA中DA的含量为约14.09％。然后，在GelDA分子链上的氨基与OSA分子链上的醛基之间进行席夫碱反应，制备了OSA-GelDA粘性水凝胶。最后，通过改变添加到OSA-GelDA凝胶中的ACP / DA / Ag3颗粒的含量，研究了材料的相应性能。结果表明，多巴胺的引入为水凝胶提供了湿粘度，而粘稠的水凝胶中引入的ACP / DA / Ag3颗粒则提供了抗菌性能。这种具有抗菌和湿粘度的水凝胶有望成为临床上可注射的骨修复材料。