The very recent Covid-19 pandemic has made the need to understand biocompatible polymers as support material in drug delivery systems and controlled release clearer, especially for organo-hydrogels. This study aims to synthesize various new polymeric materials called gels, hydrogels, and organo-hydrogels according to the monomer used and to investigate their use as drug release systems. The agar-glycerol (AG) pair was used to synthesize the polymers, N, N, methylene bisacrylamide (MBA, m) and glutaraldehyde (GA, g) were used as cross-linkers and peppermint oil (PmO) was included to obtain the organo-hydrogels. Therefore, one AG gel and two p (AG-m) and p (GA-g) hydrogels were synthesized within the scope of the study. Six different organo-hydrogels based on p(AG-m-PmO) or p (AG-g-PmO) were also synthesized by varying the amount of peppermint oil. Paracetamol and carboplatin were selected as the sample drugs. Synthesized gels, hydrogels and organo-hydrogels were characterized by FTIR and SEM analysis. Additionally, swelling behaviors of the synthesized gels were investigated in different media (ID water, tap water, ethanol, acetone, ethanol/ID water (1:1), acetone/ID water (1:1) and gasoline) and at different pHs. Moreover, it was determined that organo-hydrogels were blood compatible and had antioxidant properties based on hemolysis, blood clotting and antioxidant analysis. Therefore, the release of paracetamol (a known antipyretic-painkiller, recommended and used in the treatment of Covid-19) and carboplatin (widely used in cancer treatment) were studied. Evidently, as the amount of PMO oil increases, the -OH groups in organo-hydrogels will increase and the chemical and physical bonding rates will increase; therefore it was observed that increasing peppermint oil in the organo-hydrogels structure to 0.3 mL stimulated the release of the drugs. For instance, maximum paracetamol release amount from p(AG-g-PmO) and p(AG-m-PmO) organo-hydrogels was calculated to be 72.3% at pH 7.4 and 69.8% at pH 2.0, respectively. The maximum carboplatin release amount from p(AG-g-PmO) and p(AG-m-PmO) organo-hydrogels was calculated to be 99.7% at pH 7.4 and 100% at pH 7.4, respectively. It was concluded that the synthesized organo-hydrogels might easily be used as drug carrier and controlled drug release materials.

最近的 Covid-19 大流行使得需要将生物相容性聚合物理解为药物输送系统中的支持材料和更清晰的控释材料，尤其是对于有机水凝胶。本研究旨在根据所使用的单体合成各种称为凝胶、水凝胶和有机水凝胶的新型聚合物材料，并研究它们作为药物释放系统的用途。琼脂-甘油 (AG) 对用于合成聚合物，N、N、亚甲基双丙烯酰胺 (MBA, m) 和戊二醛 (GA, g) 用作交联剂，并加入薄荷油 (PmO) 以获得有机水凝胶。因此，在研究范围内合成了一种 AG 凝胶和两种 p (AG-m) 和 p (GA-g) 水凝胶。还通过改变薄荷油的量合成了基于 p(AG-m-PmO) 或 p (AG-g-PmO) 的六种不同有机水凝胶。选择对乙酰氨基酚和卡铂作为样品药物。通过 FTIR 和 SEM 分析对合成的凝胶、水凝胶和有机水凝胶进行了表征。此外，还研究了合成凝胶在不同介质（ID 水、自来水、乙醇、丙酮、乙醇/ID 水 (1:1)、丙酮/ID 水 (1:1) 和汽油）和不同 pH 值下的溶胀行为. 此外，基于溶血、血液凝固和抗氧化分析，确定有机水凝胶与血液相容并具有抗氧化特性。因此，对扑热息痛（一种已知的解热止痛药，推荐并用于治疗 Covid-19）和卡铂（广泛用于癌症治疗）的释放进行了研究。显然，随着 PMO 油量的增加，有机水凝胶中的-OH基团会增加，化学和物理键合率会增加；因此观察到将有机水凝胶结构中的薄荷油增加到 0.3 mL 会刺激药物的释放。例如，p(AG-g-PmO) 和 p(AG-m-PmO) 有机水凝胶的最大对乙酰氨基酚释放量在 pH 7.4 和 2.0 时分别计算为 72.3% 和 69.8%。p(AG-g-PmO) 和 p(AG-m-PmO) 有机水凝胶的最大卡铂释放量在 pH 7.4 和 pH 7.4 时分别计算为 99.7% 和 100%。结论是合成的有机水凝胶可以很容易地用作药物载体和控释材料。3毫升刺激药物的释放。例如，p(AG-g-PmO) 和 p(AG-m-PmO) 有机水凝胶的最大对乙酰氨基酚释放量在 pH 7.4 和 2.0 时分别计算为 72.3% 和 69.8%。p(AG-g-PmO) 和 p(AG-m-PmO) 有机水凝胶的最大卡铂释放量在 pH 7.4 和 pH 7.4 时分别计算为 99.7% 和 100%。结论是合成的有机水凝胶可以很容易地用作药物载体和控释材料。3毫升刺激药物的释放。例如，p(AG-g-PmO) 和 p(AG-m-PmO) 有机水凝胶的最大对乙酰氨基酚释放量在 pH 7.4 和 2.0 时分别计算为 72.3% 和 69.8%。p(AG-g-PmO) 和 p(AG-m-PmO) 有机水凝胶的最大卡铂释放量在 pH 7.4 和 pH 7.4 时分别计算为 99.7% 和 100%。结论是合成的有机水凝胶可以很容易地用作药物载体和控释材料。