The repair of abdominal wall defects often requires the use of polypropylene (PP) as the main material. After a PP mesh is implanted in the body, contact with the intestine can cause adhesions between the intestine and the mesh, leading to serious complications such as intestinal fistula. In this study, we used electrostatic spinning technology to coat one side of PP meshes with an electrostatically spun isolating layer of acellular dermal matrix (ADM)/silk fibroin (SF) hybrid material. These meshes were used to repair abdominal wall defects in model rats and were compared with polycaprolactone (PCL) composite polypropylene meshes and PP meshes. The results showed that the adhesion score and area of ADM/SF-PP meshes were smaller than those of PCL-PP and PP meshes. Immunohistochemical assessment revealed that the ADM/SF meshes could effectively reduce the inflammatory response at the contact surface between the meshes and abdominal organs. The tissues regenerated on the abdominal side were rich in new blood vessels. Furthermore, the ADM/SF meshes could effectively reduce the expression levels of the inflammation-related factors IL-6 and TNF-α. The expression levels of tissue regeneration-related factors, such as VEGF and PAX-7, were also higher after ADM/SF-PP mesh-mediated repair than after PCL-PP mesh and PP mesh repair. Thus, ADM/SF-PP meshes can effectively reduce the inflammatory response at the contact surface between the meshes and abdominal organs and quickly promote regeneration of abdominal surface tissue to prevent and reduce abdominal adhesion and support restoration of the abdominal wall.

腹壁缺损的修复通常需要使用聚丙烯（PP）作为主要材料。将PP网布植入体内后，与肠接触会引起肠与网之间的粘连，从而导致严重的并发症，例如肠瘘。在这项研究中，我们使用静电纺丝技术在无纺布真皮基质（ADM）/丝素蛋白（SF）杂化材料的静电纺丝隔离层上覆盖PP网的一侧。这些网片用于修复模型大鼠的腹壁缺损，并与聚己内酯（PCL）复合聚丙烯网片和PP网片进行比较。结果表明，ADM / SF-PP网片的附着力得分和面积均小于PCL-PP和PP网片。免疫组织化学评估显示，ADM / SF网片可有效减少网片与腹部器官接触表面的炎症反应。在腹部再生的组织富含新血管。此外，ADM / SF网格可以有效降低炎症相关因子IL-6和TNF-α的表达水平。ADM / SF-PP网格介导的修复后，组织再生相关因子（如VEGF和PAX-7）的表达水平也高于PCL-PP网格和PP网格修复后的表达水平。因此，ADM / SF-PP网可以有效地减少网与腹部器官之间接触表面的炎症反应，并迅速促进腹部表面组织的再生，从而防止和减少腹部粘连并支持腹壁的恢复。