Background

To our knowledge, disease burden of atopic dermatitis (AD) as number of days with symptoms and medical treatment has never been studied as measure of severity.

Objectives

To investigate risk factors for AD burden in the first 3 years of life.

Methods

The Copenhagen Prospective Studies on Asthma in Childhood₂₀₁₀ included 700 children. AD burden was assessed by daily diary entries with information on AD and steroid days measuring 18 possible heritable, prenatal, and postnatal environmental exposures.

Results

The children with AD had a median (interquartile range) of 136 symptom days (61-294 days) and 72 steroid days (27-145 days) during the first 3 years of life, with the highest disease burden in the second year of life. The multivariable risk factor analysis showed that maternal AD and childhood allergic sensitization were associated with a higher number of AD days and maternal AD, filaggrin mutation, and allergic sensitization were associated with a higher number of steroid days.

Limitations

Participants with a personal interest in atopic diseases could be more likely to participate.

Conclusion

Children's burden of AD, assessed quantitatively as AD and steroid days, demonstrated positive associations with maternal AD, filaggrin mutation, and early-life allergic sensitization, with the highest disease burden in the second year of life.

中文翻译：

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通过每天监测症状和局部使用类固醇激素来评估儿童早期特应性皮炎的症状负担

背景

据我们所知，从未研究过特应性皮炎（AD）的疾病负担，即出现症状的天数和药物治疗的严重程度。

目标

调查生命最初3年中AD负担的危险因素。

方法

哥本哈根_2010年儿童哮喘研究的前瞻性研究包括700名儿童。通过每日日记条目评估AD负担，并提供有关AD和类固醇日的信息，这些信息可测量18种可能的遗传，产前和产后环境暴露。

结果

患有AD的儿童在生命的前3年中位数（四分位间距）为136症状日（61-294天），类固醇为72天（27-145天），在生命的第二年中疾病负担最高。多变量危险因素分析显示，母亲AD和儿童过敏性过敏与较高的AD天相关，母亲AD，丝蛋白突变和过敏性致敏与较高类固醇天相关。

局限性

对过敏性疾病有个人兴趣的参与者更有可能参加。

结论

儿童的AD负担（以AD和类固醇天数进行定量评估）显示出与母体AD，丝聚蛋白突变和生命早期的过敏性过敏症呈正相关，而在第二年的疾病负担最高。