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Fluorescent antibiotics for real-time tracking of pathogenic bacteria
Journal of Pharmaceutical Analysis ( IF 8.8 ) Pub Date : 2020-09-18 , DOI: 10.1016/j.jpha.2020.09.003
Lu Miao , Weiwei Liu , Qinglong Qiao , Xiaolian Li , Zhaochao Xu

The harm of pathogenic bacteria to humans has promoted extensive research on physiological processes of pathogens, such as the mechanism of bacterial infection, antibiotic mode of action, and bacterial antimicrobial resistance. Most of these processes can be better investigated by timely tracking of fluorophore-derived antibiotics in living cells. In this paper, we will review the recent development of fluorescent antibiotics featuring the conjugation with various fluorophores, and focus on their applications in fluorescent imaging and real-time detection for various physiological processes of bacteria in vivo.



中文翻译:

荧光抗生素可实时追踪病原菌

病原细菌对人类的危害促进了对病原体生理过程的广泛研究,例如细菌感染的机制,抗生素的作用方式和细菌的抗药性。通过及时跟踪活细胞中荧光团衍生的抗生素,可以更好地研究其中的大多数过程。在本文中,我们将回顾与各种荧光团结合的荧光抗生素的最新发展,并将重点介绍其在荧光成像和体内各种细菌生理过程的实时检测中的应用。

更新日期:2020-10-30
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