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Effect of cyclodextrin types and reagents solvation on the stability of complexes between B-cyclodextrins and rutin in water-ethanol solvents
Journal of Molecular Liquids ( IF 6 ) Pub Date : 2020-09-19 , DOI: 10.1016/j.molliq.2020.114308
Thi Lan Pham , T.R. Usacheva , I.A. Kuz'mina , Thi Ngoan Nguyen , Hoang Thai , M.A. Volkova , Hai Khoa Le , Tuan Dung Nguyen , V.A. Volynkin , Dai Lam Tran

In this work, the solubility of rutin was first obtained in the water-ethanol solvents with small composition of co-solvent in the mixture at 25 °C. The results showed that the solubility of rutin improved with increasing ethanol content in the studied range 0–0.1 mol. fr. Solvation of hydroxypropyl-β-cyclodextrin in binary solvents was first studied by the method of interfacial distribution of the substance between two immiscible phases. It was found that when moving hydroxypropyl-β-cyclodextrin from water to the water-ethanol solvent, a decrease in the solvation of hydroxypropyl-β-cyclodextrin was observed. Complexation between rutin and β-cyclodextrin or hydroxypropyl-β-cyclodextrin was also studied in water and in the water-ethanol solvents. In the aqueous solution containing hydroxypropyl-β-cyclodextrin, the solubility of rutin was improved significantly and better than in the solution containing β-cyclodextrin. The stability of (rutin-hydroxypropyl-β-cyclodextrin) complex decreased with increasing the ethanol content and was determined by the sum of solvation of rutin (ΔtrGRuT) and hydroxypropyl-β-cyclodextrin (ΔtrGHPβCD). This effect was also observed for the complexation reaction between quercetin and hydroxypropyl-β-cyclodextrin in our previous study.



中文翻译:

环糊精类型和试剂溶剂化对水-乙醇溶剂中B-环糊精与芦丁配合物稳定性的影响

在这项工作中,首先在25°C的混合物中以少量共溶剂组成的水-乙醇溶剂获得芦丁的溶解度。结果表明,在0-0.1 mol的研究范围内,芦丁的溶解度随乙醇含量的增加而提高。fr。首先在二元溶剂中溶解羟丙基-β-环糊精通过物质在两个不混溶相之间的界面分布方法进行了研究。发现当将羟丙基-β-环糊精从水移至水-乙醇溶剂中时,观察到羟丙基-β-环糊精的溶剂化降低。还研究了芦丁与β-环糊精或羟丙基-β-环糊精之间的络合作用。在含有羟丙基-β-环糊精的水溶液中,芦丁的溶解度比含有β-环糊精的溶液显着提高并且更好。(芦丁羟丙基β环糊精)的稳定性复杂随着乙醇含量减少和由芦丁(Δ的溶剂化的总和被确定TR ģ RUT)和羟丙基β环糊精(ΔTR ģ HPβCD)。在我们以前的研究中,槲皮素和羟丙基-β-环糊精之间的络合反应也观察到了这种作用。

更新日期:2020-09-20
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