Abstract Linagliptin (LGP) is a novel hypoglycemic drug that belongs to the dipeptidyl-peptidase-4 inhibitor class that was approved in 2011 for the treatment of type 2 diabetes. Today, the integration of different materials and electrochemistry has opened a new horizon to develop highly selective, sensitive, rapid and reliable techniques to detect and quantify such vital analytes. The purpose of this article is to develop an improved carbon paste electrode (CPE) with graphitic carbon nitride/β-cyclodextrin nanocomposite (gCN-βCD/CPE) as an electrochemical sensor for the measurement of LGP. For this purpose, gCN was synthesized from melamine and mixed with βCD to obtain a nanocomposite for the chemical modification of CPE. The influence of modifier on the selectivity, sensitivity, response and lifetime of the CPE was investigated. The results show that the developed LGP electrochemical determination method has a broad range of linearity from 0.01 to 50 μM (R2 > 0.986) based on differential pulse voltammetry (DPV) responses. The detection limit of the method was 3 nM and the probable interference influence on the analytical signal of LGP was insignificant. The improved electrode was successfully used to measure LGP in the blood serum sample with a satisfactory relative recovery (>95.6%).

中文翻译：

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基于氮化碳-β-环糊精纳米复合材料作为改性剂的利格列汀电化学传感器

摘要 利格列汀（ LGP ）是一种新型降糖药，属于二肽基肽酶 4 抑制剂类，于 2011 年获批用于治疗 2 型糖尿病。今天，不同材料和电化学的整合为开发高选择性、灵敏、快速和可靠的技术来检测和量化这些重要分析物开辟了新的视野。本文的目的是开发一种改进的碳糊电极 (CPE)，它采用石墨氮化碳/β-环糊精纳米复合材料 (gCN-βCD/CPE) 作为电化学传感器，用于测量 LGP。为此，由三聚氰胺合成 gCN 并与 βCD 混合以获得用于 CPE 化学改性的纳米复合材料。研究了改性剂对 CPE 的选择性、灵敏度、响应和寿命的影响。结果表明，基于差分脉冲伏安法 (DPV) 响应，开发的 LGP 电化学测定方法具有从 0.01 到 50 μM (R2 > 0.986) 的广泛线性范围。该方法的检测限为3 nM，对导光板分析信号的可能干扰影响不显着。改进后的电极成功地用于测量血清样品中的 LGP，具有令人满意的相对回收率 (>95.6%)。