Animals' ability to sense environmental cues and to integrate this information to control fecundity is vital for continuing the species lineage. In this study, we observed that the sensory neurons Amphid neuron (ASHs and ADLs) differentially regulate egg-laying behavior in Caenorhabditis elegans under varied environmental conditions via distinct neuronal circuits. Under standard culture conditions, ASHs tonically release a small amount of glutamate and inhibit Hermaphrodite specific motor neuron (HSN) activities and egg laying via a highly sensitive Glutamate receptor (GLR)-5 receptor. In contrast, under Cu²⁺ stimulation, ASHs and ADLs may release a large amount of glutamate and inhibit Amphid interneuron (AIA) interneurons via low-sensitivity Glutamate-gated chloride channel (GLC)-3 receptor, thus removing the inhibitory roles of AIAs on HSN activity and egg laying. However, directly measuring the amount of glutamate released by sensory neurons under different conditions and assaying the binding kinetics of receptors with the neurotransmitter are still required to support this study directly.

动物感知环境线索并整合这些信息以控制繁殖力的能力对于继续物种传承至关重要。在这项研究中，我们观察到感觉神经元两栖神经元（ASHs和ADLs）在不同环境条件下通过不同的神经元回路差异性调节秀丽隐杆线虫的产卵行为。在标准培养条件下，ASH通过高敏感性谷氨酸受体（GLR）-5受体来调释少量谷氨酸并抑制雌雄同体特异性运动神经元（HSN）活性和产卵。相反，在Cu ^2+下刺激中，ASH和ADL可能会通过低敏感性谷氨酸盐酸盐-氯离子通道（GLC）-3受体释放大量的谷氨酸盐并抑制两性中间神经元（AIA）内部神经元，从而消除了AIAs对HSN活性和产卵的抑制作用。然而，直接支持这项研究仍然需要直接测量在不同条件下由感觉神经元释放的谷氨酸的量，并测定受体与神经递质的结合动力学。