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Incredible pharmaceutical residues in human milk in a cohort study from Şanlıurfa in Turkey.
Environmental Toxicology and Pharmacology ( IF 4.3 ) Pub Date : 2020-09-19 , DOI: 10.1016/j.etap.2020.103502
Sıddıka Songül Yalçin 1 , Bülent Güneş 2 , Suzan Yalçin 3
Affiliation  

Maternal milk is essential for optimum growth and development of an infant. The aim was to examine the presence of pharmaceutical residuals in breastmilk. This cohort study enrolled 90 healthy mother-infant pairs at 5−14 days after delivery and a control examination was performed 4–8 weeks later. Milk samples were taken at both visits. RANDOX Infiniplex kit performed residual analysis. More than half of mothers (54.4 %) had anti-inflammatory drug residues in at least one milk sample: those were 52.2 % for tolfenamic acid and 2.2 % for meloxicam and 1.1 % for metamizole. The most frequent residue group included the beta-lactam antibiotic group, which was detected in 93.3 % of mothers’ milk. The second one was the quinolone group (81.1 %). One-third of mothers expressed nitroxynil and one-fifth polymyxin in at least one sample. Almost all mothers had some unexpected drug residues in their milk. Additional studies from other countries can display maternal environmental exposures.



中文翻译:

土耳其Şanlıurfa进行的一项队列研究显示了人乳中难以置信的药物残留。

母乳对于婴儿的最佳生长和发育至关重要。目的是检查母乳中药物残留的存在。这项队列研究在分娩后5-14天招募了90对健康的母婴,并在4-8周后进行了对照检查。两次访问均采集牛奶样品。RANDOX Infiniplex试剂盒进行了残留分析。至少有一半的母亲中,有一半以上的母亲(54.4%)的抗炎药残留量为:托芬那酸为52.2%,美洛昔康为2.2%,美托咪唑为1.1%。最常见的残留物组包括β-内酰胺类抗生素组,在93.3%的母乳中检出。第二个是喹诺酮组(81.1%)。至少有一个样本中有三分之一的母亲表达了硝苯腈和五分之一多粘菌素。几乎所有母亲的牛奶中都有一些意外的药物残留。其他国家的其他研究也可以显示孕妇的环境暴露。

更新日期:2020-10-07
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