Integrins are transmembrane glycoproteins that are broadly distributed in living organisms. As a heterodimer, they contain an α and a β subunit, which are reported to be associated with various physiological and pathological processes. In the present study, a 2502 bp full-length cDNA sequence of Bmintegrin β1 was obtained from the silkworm, Bombyx mori. Bmintegrin β1 belongs to the β subunit of the integrin family and contains several typical structures of integrins. Gene expression profile analysis demonstrated that Bmintegrin β1 was ubiquitously expressed in all tested tissues and organs, with the maximum expression levels in fat body and hemocytes. The immunofluorescence results showed that Bmintegrin β1 was located in the cell membrane and widely distributed in fat bodies and different types of hemocytes. Bmintegrin β1 expression was remarkably increased after challenging with different kinds of bacteria and pathogen-associated molecular patterns (PAMPs). Further investigation revealed that Bmintegrin β1 could participate in the agglutination of pathogenic bacteria possibly through direct binding with the relative bacteria and PAMPs. Altogether, this study provides a novel insight into the immune functional features of Bmintegrin β1.

整联蛋白是广泛分布于生物体中的跨膜糖蛋白。作为异二聚体，它们包含一个 α 和一个 β 亚基，据报道它们与各种生理和病理过程有关。本研究从家蚕Bombyx mori中获得了 2502 bp 的Bmintegrin β1全长 cDNA 序列。Bmintegrin β1 属于整合素家族的β亚基，包含几种典型的整合素结构。基因表达谱分析表明Bmintegrin β1在所有被测组织和器官中普遍表达，在脂肪体和血细胞中表达水平最高。免疫荧光结果显示Bmintegrin β1位于细胞膜上，广泛分布于脂肪体和不同类型的血细胞中。在用不同种类的细菌和病原体相关分子模式 (PAMP) 进行攻击后， Bmintegrin β1的表达显着增加。进一步研究表明，Bmintegrin β1可能通过与相关细菌和PAMPs的直接结合参与病原菌的凝集。总之，这项研究为 Bmintegrin β1 的免疫功能特征提供了新的见解。