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Novel design of additive manufactured hollow porous implants.
Dental Materials ( IF 5 ) Pub Date : 2020-09-19 , DOI: 10.1016/j.dental.2020.08.011
Chih-Chieh Huang,Ming-Jun Li,Pei-I Tsai,Pei-Ching Kung,San-Yuan Chen,Jui-Sheng Sun,Nien-Ti Tsou

Objective

Our aim is to examine the mechanical properties of two types of additive manufactured hollow porous dental implants and 6 and 12-week bone ingrowth after insertion in animals. A 3D numerical model is also developed to show detailed tissue differentiation and to provide design guidelines for implants.

Methods

The two porous and a commercial dental implant were studied by series of in vitro mechanical tests (three-point bending, torsional, screwing torque, and sawbone pull-out tests). They also evaluated by in vivo animal tests (micro-CT analysis) and ex vivo pull-out tests. Moreover, the mechano-regulation algorithm was implemented by the 3D finite element model to predict the history of tissue differentiation around the implants.

Results

The results showed that the two porous implants can significantly improve osseointegration after 12-week bone healing. This resulted in good fixation and stability of implants, giving very high maximum pull-out strength 413.1 N and 493.2 N, compared to 245.7 N for the commercial implant. Also, several features were accurately predicted by the mechano-regulation model, such as transversely connected bone formation, and bone resorption occurred in the middle of implants.

Significance

Systematic studies on dental implants with multiple approaches, including new design, mechanical tests, animal tests, and numerical modeling, were performed. Two hollow porous implants significantly improved bone ingrowth compared with commercial implants, while maintaining mechanical strength. Also, the numerical model was verified by animal tests. It improved the efficiency of design and reduce the demand for animal sacrifice.



中文翻译:

添加剂制造的空心多孔植入物的新颖设计。

目的

我们的目的是检查两种类型的添加剂制造的中空多孔牙科植入物的力学性能,以及在动物体内插入后6周和12周骨骼的向内生长。还开发了3D数值模型以显示详细的组织分化并为植入物提供设计指导。

方法

通过一系列体外机械测试(三点弯曲,扭转,拧紧扭矩和锯骨拔出测试)研究了这两种多孔和商用牙科植入物。他们还通过体内动物试验(微型CT分析)和离体拔出试验进行了评估。此外,通过3D有限元模型实现了机械调节算法,以预测植入物周围组织的分化历史。

结果

结果表明,两种多孔植入物可在12周骨愈合后显着改善骨整合。这导致植入物的良好固定和稳定性,与商用植入物的245.7 N相比,具有非常高的最大抗拉强度413.1 N和493.2N。此外,机械调节模型可准确预测几个特征,例如横向连接的骨形成,并且骨吸收发生在植入物的中间。

意义

对牙科植入物采用多种方法进行了系统研究,包括新设计,机械测试,动物测试和数值建模。与商用植入物相比,两种中空多孔植入物显着改善了骨向内生长,同时保持了机械强度。另外,通过动物试验验证了数值模型。它提高了设计效率,减少了对动物牺牲的需求。

更新日期:2020-10-30
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