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Bio-inspired cellulose reinforced anisotropic composite hydrogel with zone-dependent complex mechanical adaptability and cell recruitment characteristics
Composites Part B: Engineering ( IF 13.1 ) Pub Date : 2020-09-19 , DOI: 10.1016/j.compositesb.2020.108418
Dingqian Wang , Hao Xu , Jinming Liu , Zhuoxin Chen , Yanyan Li , Bohan Hu , Dongyue Zhang , Jianshu Li , Hetao Chu

Articular cartilage, due to its avascular nature and the low cell density, is hard to regenerate once damaged, thus requiring surgical intervention. Natural cartilage exhibits a complex anisotropic feature with nonlinear and viscoelastic mechanical properties owning to complicated architecture making it attractive to mimic the structure. Here, we demonstrate a three-zone composite hydrogel with superficial, middle and deep zones incorporating into cellulose fabric, cellulose nanofiber and wood cellulose fiber respectively to prepare a stack layout composite hydrogel inspired by cartilage architecture with zone-dependent mechanical properties. The results indicate that the three-zone cellulose reinforced polyethylene glycol-based composite hydrogel demonstrates hydrogel creates native-like articular cartilage with zone-dependent, nonlinear and viscoelastic mechanical properties. The compressive moduli of the superficial, middle and deep zones are 298 kPa, 182 kPa and 9.8 MPa respectively, and the middle zone possess obvious nonlinear features. Furthermore, the highly aligned wood frame channels endow deep zone with nutrition and cell transport behaviors which are beneficial to the process of cartilage regeneration. Therefore, the bio-inspired three-zone composite hydrogel has a promising potential application for cartilage repair.



中文翻译:

具有区域依赖性复杂机械适应性和细胞募集特性的生物启发纤维素增强各向异性复合水凝胶

关节软骨由于其无血管性质和低细胞密度,一旦受损就很难再生,因此需要手术干预。天然软骨表现出复杂的各向异性特征,具有复杂的结构,具有非线性和粘弹性的机械性能,使其具有模仿结构的吸引力。在这里,我们展示了一种三区域复合水凝胶,其表面,中部和深部区域分别掺入了纤维素织物,纤维素纳米纤维和木质纤维素纤维中,从而制备了具有软骨依赖性结构特性的软骨结构,从而获得了堆叠式复合水凝胶。结果表明,三区纤维素增强的聚乙二醇基复合水凝胶表明水凝胶可产生天然的关节软骨,具有区域依赖性,非线性和粘弹性力学性能。浅层,中层和深层的压缩模量分别为298 kPa,182 kPa和9.8 MPa,中层具有明显的非线性特征。此外,高度对准的木框架通道赋予深层区域营养和细胞运输行为,这对软骨再生过程有利。因此,受生物启发的三区复合水凝胶在软骨修复中具有广阔的应用前景。高度对齐的木构架通道使深层区域具有营养和细胞运输特性,这有利于软骨再生。因此,受生物启发的三区复合水凝胶在软骨修复中具有广阔的应用前景。高度对齐的木构架通道使深层区域具有营养和细胞运输特性,这有利于软骨再生。因此,受生物启发的三区复合水凝胶在软骨修复中具有广阔的应用前景。

更新日期:2020-09-23
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