Abstract There are numerous methods for producing scaffolds to be applied in bone tissue engineering. However, the best method of scaffold production is essential to consider, with respect to their chemical composition and mechanical and structural properties, so that debris is not produced when the scaffolds are evaluated in vitro or in vivo. The primary aim of the present investigation was to produce six novel β-TCP scaffold compositions, using sodium chloride as a porogen, with two different particle sizes, measuring 1–2 mm and 750 mm-1mm, and at varied concentrations (30, 50, and 70 wt %). Physical, chemical, mechanical, and in vitro characterizations were then performed on each scaffold composition, using artificial saliva, for 7 and 14 days, with promising results. The XRD diffractograms showed the formation of two new crystalline phases (NaCaPO4 and Ca5[PO4]3Cl) in the scaffolds, after their production. In addition, scaffold porosity, Young's modulus, and the maximum resistance of compression values were in the trabecular bone range and the in vitro test, using artificial saliva, was favorable in relation to scaffold bioactivity.

中文翻译：

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使用 NaCl 作为用于骨组织应用的致孔剂生产新型 β-TCP 支架

摘要 有多种制备支架的方法可应用于骨组织工程。然而，支架生产的最佳方法是必须考虑的，考虑到它们的化学成分和机械和结构特性，以便在体外或体内评估支架时不会产生碎片。本研究的主要目的是生产六种新型 β-TCP 支架组合物，使用氯化钠作为致孔剂，具有两种不同的粒径，尺寸为 1-2 毫米和 750 毫米-1 毫米，浓度不同（30、50 ，和 70 重量％）。然后使用人工唾液对每个支架组合物进行了 7 天和 14 天的物理、化学、机械和体外表征，结果令人鼓舞。XRD 衍射图显示在支架生产后形成了两个新的结晶相（NaCaPO4 和 Ca5[PO4]3Cl）。此外，支架孔隙率、杨氏模量和最大抗压值均在骨小梁范围内，使用人工唾液的体外试验对支架生物活性有利。