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Polymer colloids as drug delivery systems for the treatment of arthritis
Advances in Colloid and Interface Science ( IF 15.6 ) Pub Date : 2020-09-18 , DOI: 10.1016/j.cis.2020.102273
Tahani Saeedi 1 , Hadil Faris Alotaibi 2 , Polina Prokopovich 1
Affiliation  

The most common types of arthritis are osteoarthritis (OA) and rheumatoid arthritis (RA) which are themain causes of disability and pain among older people. Current treatment of arthritis mainly consists of oral and intra-articular medications. Despite the efficacy of the intraarticular injections over the oral treatment, it is still limited by the rapid clearance of the injected drug. Therefore, a rational design of drug delivery systems (DDSs) able to delivery drugs in controlled manner and for required period of time to the arthritis joint is a key in developing safe and effective formulations for OA and RA. In this paper various colloidal systems like nanoparticles, liposomes, cationic carriers, hydrogels, and emulsion-based carriers were presented and discussed in light of their use and efficacy as delivery systems to transport therapeutics for arthritis treatment. Factors influencing the delivery efficacy such as size, charge, structure, drug uptake, retention and its release profile alongside with cytocompatibility and safety were addressed. Moreover, the advantages and disadvantages of the different colloidal systems were emphasised.



中文翻译:

聚合物胶体作为用于治疗关节炎的药物递送系统

最常见的关节炎类型是骨关节炎 (OA) 和类风湿性关节炎 (RA),它们是老年人残疾和疼痛的主要原因。目前关节炎的治疗主要包括口服和关节内药物治疗。尽管关节内注射优于口服治疗,但仍受到注射药物快速清除的限制。因此,能够以受控方式和所需时间将药物递送至关节炎关节的药物递送系统 (DDS) 的合理设计是开发用于 OA 和 RA 的安全有效制剂的关键。在本文中,各种胶体系统,如纳米颗粒、脂质体、阳离子载体、水凝胶、介绍和讨论了基于乳液的载体作为递送系统的用途和功效,以运输治疗关节炎的治疗剂。解决了影响递送效率的因素,例如大小、电荷、结构、药物吸收、保留及其释放曲线以及细胞相容性和安全性。此外,还强调了不同胶体体系的优缺点。

更新日期:2020-09-29
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