Phytochemistry Reviews ( IF 7.7 ) Pub Date : 2020-09-18 , DOI: 10.1007/s11101-020-09720-6 Julia Solnier 1 , Johannes-Paul Fladerer 1
COVID-19, the highly contagious novel disease caused by SARS-CoV-2, has become a major international concern as it has spread quickly all over the globe. However, scientific knowledge and therapeutic treatment options for this new coronavirus remain limited. Although previous outbreaks of human coronaviruses (CoVs) such as SARS and MERS stimulated research, there are, to date, no antiviral therapeutics available that specifically target these kinds of viruses. Natural compounds with a great diversity of chemical structures may provide an alternative approach for the discovery of new antivirals. In fact, numerous flavonoids were found to have antiviral effects against SARS-and MERS-CoV by mainly inhibiting the enzymes 3-chymotrypsin-like protease (3CLpro) and papain-like protease (PLpro). In this review, we specifically focused on the search for flavonoids, polyphenolic compounds, which are proven to be effective against human CoVs. We therefore summarized and analyzed the latest progress in research to identify flavonoids for antiviral therapy and proposed strategies for future work on medicinal plants against coronaviruses such as SARS-CoV-2. We discovered quercetin, herbacetin, and isobavachalcone as the most promising flavonoids with anti-CoV potential.
中文翻译:
黄酮类化合物:COVID-19 常规疗法的补充方法?
COVID-19 是由 SARS-CoV-2 引起的具有高度传染性的新型疾病,随着它在全球范围内迅速传播,已成为国际关注的主要问题。然而,针对这种新型冠状病毒的科学知识和治疗选择仍然有限。尽管之前爆发的 SARS 和 MERS 等人类冠状病毒 (CoV) 刺激了研究,但迄今为止,还没有专门针对此类病毒的抗病毒疗法。具有多种化学结构的天然化合物可以为发现新的抗病毒药物提供另一种方法。事实上,许多黄酮类化合物被发现对 SARS 和 MERS-CoV 具有抗病毒作用,主要是通过抑制酶 3-糜蛋白酶样蛋白酶 (3CLpro) 和木瓜蛋白酶样蛋白酶 (PLpro)。在本次审查中,我们特别专注于寻找黄酮类化合物、多酚类化合物,这些化合物已被证明对人类冠状病毒有效。因此,我们总结和分析了确定黄酮类化合物用于抗病毒治疗的最新研究进展,并提出了未来药用植物抗冠状病毒(如 SARS-CoV-2)的工作策略。我们发现槲皮素、草本素和异巴伐查酮是最有前景的具有抗冠状病毒潜力的黄酮类化合物。