Geometrical modification of three electrode Clark sensor is performed to enhance the sensing amperometric current. Two types of implantable microsensors are designed and characterized for measuring dissolved oxygen (DO₂). For type I sensor, the area of the reference electrode (RE) conventionally sandwiched between working electrode (WE) and counter electrode (CE), is optimized. In contrast to the conventional Clark sensors, the CE is sandwiched between WE and RE in type II sensor. Both type microsensors are fabricated using simple processes of silicon-based microfabrication technology. Electrochemical characterizations are performed on both sensors. For 96% DO₂, type I and type II microsensors demonstrate a sensing current of $- 0.87\,\,\mu \text{A}$ and $- 2.35\,\,\mu \text{A}$ as compared to a sensing current of $- 0.27\,\,\mu \text{A}$ for the conventional Clark microsensor of same size. A sensitivity of $0.0094~\mu \text{A}$ /%DO₂ and $0.024~\mu \text{A}$ /%DO₂ are achieved with type I and type II microsensor, respectively in contrast to a sensitivity of $0.0027~\mu \text{A}$ /%DO₂ of the conventional Clark microsensor of same size. The sensors show a lifetime of 48 hours. With its miniature size and enhanced sensing current the sensors have potentials for clinical and biomedical applications.

中文翻译：

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具有增强感测电流的改良型 Clark 微传感器

对三电极克拉克传感器进行几何修改以增强感应电流。两种类型的植入式微传感器被设计和表征用于测量溶解氧 (DO ₂ )。对于 I 型传感器，优化了通常夹在工作电极 (WE) 和对电极 (CE) 之间的参比电极 (RE) 的面积。与传统的克拉克传感器相比，在 II 型传感器中，CE 夹在 WE 和 RE 之间。两种类型的微传感器都是使用基于硅的微制造技术的简单工艺制造的。在两个传感器上进行电化学表征。对于 96% DO ₂，I 型和 II 型微传感器的感测电流为 $- 0.87\,\,\mu \text{A}$ 和 $- 2.35\,\,\mu \text{A}$ 与感应电流相比 $- 0.27\,\,\mu \text{A}$ 对于相同尺寸的传统克拉克微传感器。一个敏感度 $0.0094~\mu \text{A}$ /%DO ₂和 $0.024~\mu \text{A}$ /%DO ₂分别通过 I 型和 II 型微传感器实现，而灵敏度为 $0.0027~\mu \text{A}$ /%DO ₂的相同尺寸的常规克拉克微传感器。传感器的使用寿命为 48 小时。凭借其微型尺寸和增强的感测电流，这些传感器具有临床和生物医学应用的潜力。