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Bacterial Natural Compounds with Anti-Inflammatory and Immunomodulatory Properties (Mini Review)
Drug Design, Development and Therapy ( IF 4.8 ) Pub Date : 2020-09-18 , DOI: 10.2147/dddt.s261283 Anahita Jenab 1 , Rasoul Roghanian 1 , Giti Emtiazi 1
Drug Design, Development and Therapy ( IF 4.8 ) Pub Date : 2020-09-18 , DOI: 10.2147/dddt.s261283 Anahita Jenab 1 , Rasoul Roghanian 1 , Giti Emtiazi 1
Affiliation
Abstract: Inflammation is part of the body’s complex biological response to harmful stimuli such as damaged cells, pathogens, or irritants. It is a protective response involving blood cells, immune cells, and molecular mediators. The inflammation not only can eliminate the primary cause of cell injury but also clears out necrotic cells, tissue damaged from the original insults and inflammatory process. Furthermore, it can initiate tissue repair. Pro-inflammatory cytokines are produced predominantly by activated macrophages and are involved in the up-regulation of inflammatory reactions. They are involved in further regulating inflammatory reactions. There is ample evidence that some pro-inflammatory cytokines, such as interleukin 1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α), are involved in the pathological pain process. Some of the natural compounds promote cytokines production and inhibit inflammatory responses. The natural compounds which are produced from microorganisms such as omega-3 fatty acid, cyclic peptide, antimicrobial peptide, oligosaccharides, and polysaccharides can reduce inflammation and could be easily incorporated into the diet without any adverse effects. For example, SCFA (short-chain fatty acids), peptide bacteriocin, and polycyclic peptide bacteriocin (nisin) could be used in the treatment of atherosclerosis, orthopedic postoperative infections, and mycobacterium tuberculosis infection, respectively. Also, fatty acids (saturated and unsaturated fatty acids) can be introduced as anti-inflammatory drugs. This review article summarizes bacterial natural compounds with modulating effects on cytokines that are surveyed which may have potential anti-inflammatory drug-like activity.
Keywords: bacterial natural materials, secondary metabolite, drug-like activity, anti-inflammatory activity, cytokine
中文翻译:
具有抗炎和免疫调节特性的细菌天然化合物(小型评论)
摘要:炎症是人体对有害刺激(例如受损细胞,病原体或刺激物)的复杂生物反应的一部分。这是涉及血细胞,免疫细胞和分子介质的保护性反应。炎症不仅可以消除造成细胞损伤的主要原因,还可以清除坏死细胞,原始损伤和炎性过程中受损的组织。此外,它可以启动组织修复。促炎细胞因子主要由活化的巨噬细胞产生,并参与炎症反应的上调。它们参与进一步调节炎症反应。有充分的证据表明,某些促炎细胞因子,例如白介素1β(IL-1β),IL-6和肿瘤坏死因子-α(TNF-α),参与了病理性疼痛过程。一些天然化合物促进细胞因子的产生并抑制炎症反应。由微生物产生的天然化合物,例如omega-3脂肪酸,环状肽,抗微生物肽,寡糖和多糖,可以减少炎症,可以轻松地掺入饮食中而无任何不良影响。例如,SCFA(短链脂肪酸),肽菌素和多环肽菌素(乳链菌肽)可用于治疗动脉粥样硬化,骨科术后感染以及 多糖可以减少炎症,可以很容易地掺入饮食中而没有任何不良影响。例如,SCFA(短链脂肪酸),肽菌素和多环肽菌素(乳链菌肽)可用于治疗动脉粥样硬化,骨科术后感染以及 多糖可以减少炎症,可以很容易地掺入饮食中而没有任何不良影响。例如,SCFA(短链脂肪酸),肽菌素和多环肽菌素(乳链菌肽)可用于治疗动脉粥样硬化,骨科术后感染以及结核分枝杆菌分别感染。另外,可以将脂肪酸(饱和和不饱和脂肪酸)引入作为抗炎药。这篇综述文章总结了对细胞因子具有调节作用的细菌天然化合物,这些化合物可能具有潜在的抗炎药样活性。
关键词:细菌天然物质,次生代谢产物,类药物活性,抗炎活性,细胞因子
更新日期:2020-09-18
Keywords: bacterial natural materials, secondary metabolite, drug-like activity, anti-inflammatory activity, cytokine
中文翻译:
具有抗炎和免疫调节特性的细菌天然化合物(小型评论)
摘要:炎症是人体对有害刺激(例如受损细胞,病原体或刺激物)的复杂生物反应的一部分。这是涉及血细胞,免疫细胞和分子介质的保护性反应。炎症不仅可以消除造成细胞损伤的主要原因,还可以清除坏死细胞,原始损伤和炎性过程中受损的组织。此外,它可以启动组织修复。促炎细胞因子主要由活化的巨噬细胞产生,并参与炎症反应的上调。它们参与进一步调节炎症反应。有充分的证据表明,某些促炎细胞因子,例如白介素1β(IL-1β),IL-6和肿瘤坏死因子-α(TNF-α),参与了病理性疼痛过程。一些天然化合物促进细胞因子的产生并抑制炎症反应。由微生物产生的天然化合物,例如omega-3脂肪酸,环状肽,抗微生物肽,寡糖和多糖,可以减少炎症,可以轻松地掺入饮食中而无任何不良影响。例如,SCFA(短链脂肪酸),肽菌素和多环肽菌素(乳链菌肽)可用于治疗动脉粥样硬化,骨科术后感染以及 多糖可以减少炎症,可以很容易地掺入饮食中而没有任何不良影响。例如,SCFA(短链脂肪酸),肽菌素和多环肽菌素(乳链菌肽)可用于治疗动脉粥样硬化,骨科术后感染以及 多糖可以减少炎症,可以很容易地掺入饮食中而没有任何不良影响。例如,SCFA(短链脂肪酸),肽菌素和多环肽菌素(乳链菌肽)可用于治疗动脉粥样硬化,骨科术后感染以及结核分枝杆菌分别感染。另外,可以将脂肪酸(饱和和不饱和脂肪酸)引入作为抗炎药。这篇综述文章总结了对细胞因子具有调节作用的细菌天然化合物,这些化合物可能具有潜在的抗炎药样活性。
关键词:细菌天然物质,次生代谢产物,类药物活性,抗炎活性,细胞因子