Modern scientific research has shown that Acanthopanax senticosus (AS) can regulate the innate immunity of healthy animals, thus affecting the health of animals. However, there are few systematic reports on the changes of innate immune indices of healthy animals after consuming AS. The purpose of this project was to study the effect on healthy mice’s innate immunity and changes of related immune factors induced by feeding AS root powder supplementation. The results showed that the killing rate of natural cells increased in a dose-dependent manner in a certain time period. Compared to the control group, the treatment groups (T1, T2 and T3) improved significantly in the innate immune index (lysozyme, β-defensin-2 and duodenal secretory IgA (SIgA) to varying degrees) and induced corresponding changes of immune factors at certain time periods. The correlation between SIgA and IFN-γ in mouse serum was enhanced, and the higher the concentration of AS in the diet, the stronger the correlation was. However, there was no significant difference in growth performance among groups. It is proved that AS supplementation can enhance innate immunity and change several relevant immune factors and cells of healthy mice without affecting growth performance.

现代科学研究表明，刺五加(AS)可以调节健康动物的先天免疫，从而影响动物的健康。然而，关于健康动物食用AS后先天免疫指标变化的系统报道较少。本项目旨在研究饲喂AS根粉对健康小鼠先天免疫的影响及相关免疫因子的变化。结果表明，自然细胞的杀伤率在一定时间内呈剂量依赖性增加。与对照组相比，治疗组（T1、T2、T3）的先天免疫指数（溶菌酶、β-防御素-2和十二指肠分泌型IgA（SIgA）均有不同程度的提高）并诱导免疫因子发生相应变化。某些时间段。小鼠血清中 SIgA 与 IFN-γ 的相关性增强，日粮中AS浓度越高，相关性越强。然而，各组之间的生长性能没有显着差异。事实证明，补充AS可以增强先天免疫，改变健康小鼠的几种相关免疫因子和细胞，而不影响生长性能。