Little has been reported on the safety and efficacy of pituitary biopsy in the pediatric population for suspected germinoma. An updated review is needed. Patients who underwent biopsy (endoscopic endonasal vs. open craniotomy) for isolated pituitary stalk thickening were identified. Age, pre- and post-operative endocrine status, surgical approach, length of surgery, estimated blood loss, surgical morbidity, length of ICU stay, total length of stay, and pathology reports were reviewed. Nine patients met inclusion criteria. Germinoma diagnosis was rendered in 7 of 9 patients; 1 patient required two biopsy attempts. Two-patients had histology consistent with inflammation and a subsequently self-limited disease course. Average operative time, blood loss, ICU stay and overall length of stay was just over 2 h, 28 mL, 1.6 days and 3.7 days respectively. There were no intraoperative complications and all patients were discharged home. One patient developed new diabetes insipidus post-operatively. Patients who underwent endoscopic biopsy had decreased operative times and shorter hospitalizations. Biopsy for isolated pituitary stalk thickening for suspected germinoma is generally safe with high diagnostic utility. Importantly, 22% of presumed germinomas on imaging yielded alternative diagnoses on biopsy, adding support for pathology-proven data to guide treatment in relevant cases.

关于垂体活检在疑似生殖细胞瘤的儿科人群中的安全性和有效性的报道很少。需要更新审查。确定了因孤立的垂体柄增厚而接受活检（内窥镜鼻内与开颅手术）的患者。回顾了年龄、术前和术后内分泌状态、手术方式、手术时间、估计失血量、手术发病率、ICU 住院时间、总住院时间和病理报告。9 名患者符合纳入标准。9 名患者中有 7 名被诊断为生殖细胞瘤；1 名患者需要两次活检。两名患者的组织学符合炎症和随后的自限性疾病过程。平均手术时间、失血量、ICU 住院时间和总住院时间分别刚刚超过 2 小时、28 毫升、1.6 天和 3.7 天。术中无并发症，所有患者均已出院回家。一名患者术后出现新的尿崩症。接受内窥镜活检的患者手术时间减少，住院时间缩短。对疑似生殖细胞瘤的离体垂体柄增厚进行活检通常是安全的，具有很高的诊断效用。重要的是，22% 的影像学推测的生殖细胞瘤在活检时产生了替代诊断，增加了对病理学证明数据的支持，以指导相关病例的治疗。对疑似生殖细胞瘤的离体垂体柄增厚进行活检通常是安全的，具有很高的诊断效用。重要的是，22% 的影像学推测的生殖细胞瘤在活检时产生了替代诊断，增加了对病理学证明数据的支持，以指导相关病例的治疗。对疑似生殖细胞瘤的离体垂体柄增厚进行活检通常是安全的，具有很高的诊断效用。重要的是，22% 的影像学推测的生殖细胞瘤在活检时产生了替代诊断，增加了对病理学证明数据的支持，以指导相关病例的治疗。