Medical interventions increasingly rely on biosensors that can provide reliable quantitative information. A longstanding bottleneck in realizing this, is various non-idealities that generate offsets and variable responses across sensors. Current mitigation strategies involve the calibration of sensors, performed in software or via auxiliary compensation circuitry thus constraining real-time operation and integration efforts. Here, we show that bio-functionalized metal-oxide memristors can be utilized for directly transducing biomarker concentration levels to discrete memory states. The introduced chemical state-variable is found to be dependent on the devices’ initial resistance, with its response to chemical stimuli being more pronounced for higher resistive states. We leverage this attribute along with memristors’ inherent state programmability for calibrating a biosensing array to render a homogeneous response across all cells. Finally, we demonstrate the application of this technology in detecting Prostate Specific Antigen in clinically relevant levels (ng/ml), paving the way towards applications in large multi-panel assays.

医疗干预越来越依赖于能够提供可靠定量信息的生物传感器。实现这一点的一个长期瓶颈是在传感器之间产生偏移和可变响应的各种非理想情况。当前的缓解策略涉及传感器的校准，在软件中或通过辅助补偿电路执行，从而限制了实时操作和集成工作。在这里，我们展示了生物功能化金属氧化物忆阻器可用于将生物标志物浓度水平直接转换为离散记忆状态。发现引入的化学状态变量取决于器件的初始电阻，其对化学刺激的响应对于更高的电阻状态更为明显。我们利用此属性以及忆阻器的固有状态可编程性来校准生物传感阵列，以在所有细胞中呈现均匀响应。最后，我们展示了该技术在检测临床相关水平 (ng/ml) 的前列腺特异性抗原方面的应用，为大型多面板检测的应用铺平了道路。