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A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity.
Nature Communications ( IF 16.6 ) Pub Date : 2020-09-17 , DOI: 10.1038/s41467-020-18450-4
Angkana T Huang 1, 2, 3 , Bernardo Garcia-Carreras 1, 2 , Matt D T Hitchings 1, 2 , Bingyi Yang 1, 2 , Leah C Katzelnick 1, 2 , Susan M Rattigan 1, 2 , Brooke A Borgert 1, 2 , Carlos A Moreno 1, 2 , Benjamin D Solomon 4 , Luke Trimmer-Smith 1, 2 , Veronique Etienne 2, 5 , Isabel Rodriguez-Barraquer 6 , Justin Lessler 7 , Henrik Salje 1, 8, 9 , Donald S Burke 10 , Amy Wesolowski 7 , Derek A T Cummings 1, 2
Affiliation  

Many public health responses and modeled scenarios for COVID-19 outbreaks caused by SARS-CoV-2 assume that infection results in an immune response that protects individuals from future infections or illness for some amount of time. The presence or absence of protective immunity due to infection or vaccination (when available) will affect future transmission and illness severity. Here, we review the scientific literature on antibody immunity to coronaviruses, including SARS-CoV-2 as well as the related SARS-CoV, MERS-CoV and endemic human coronaviruses (HCoVs). We reviewed 2,452 abstracts and identified 491 manuscripts relevant to 5 areas of focus: 1) antibody kinetics, 2) correlates of protection, 3) immunopathogenesis, 4) antigenic diversity and cross-reactivity, and 5) population seroprevalence. While further studies of SARS-CoV-2 are necessary to determine immune responses, evidence from other coronaviruses can provide clues and guide future research.



中文翻译:

对抗体介导的冠状病毒免疫的系统评价:动力学、保护的相关性以及与严重性的关联。

许多公共卫生应对措施和针对 SARS-CoV-2 引起的 COVID-19 爆发的模拟情景都假设感染会导致免疫反应,从而在一段时间内保护个人免受未来的感染或疾病。由于感染或疫苗接种(如果有)而产生的保护性免疫力的存在或不存在将影响未来的传播和疾病的严重程度。在此,我们回顾了有关冠状病毒抗体免疫的科学文献,包括 SARS-CoV-2 以及相关的 SARS-CoV、MERS-CoV 和地方性人类冠状病毒 (HCoV)。我们审查了 2,452 篇摘要,并确定了与 5 个重点领域相关的 491 篇手稿:1) 抗体动力学,2) 保护的相关性,3) 免疫发病机制,4) 抗原多样性和交叉反应性,以及 5) 群体血清阳性率。虽然需要对 SARS-CoV-2 进行进一步研究来确定免疫反应,但其他冠状病毒的证据可以提供线索并指导未来的研究。

更新日期:2020-09-18
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