Since the onset of the COVID-19 pandemic in the fall of 2019 over 4 million people have been infected and over 280,000 have died (1). Information about the SARS-CoV2 virus is evolving rapidly. At this time there are no interventions proven to be effective for cases infected with SARS-CoV2. Current knowledge about the clinical and laboratory manifestations of COVID-19 infection is reviewed and combined with knowledge about the immunopathogenic mechanisms of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV1) and Middle East Respiratory Syndrome (MERS) to formulate theories and suggest possible therapeutic interventions. SARS-CoV2 immunopathogenic mechanisms vary from immunosuppression that initially enables viral escape to a hyperinflammatory immune response. Ultimately therapeutic intervention will be phase dependent.

自2019年秋季COVID-19大流行以来，已有超过400万人被感染，超过280,000人死亡（1个）。关于SARS-CoV2病毒的信息正在迅速发展。目前，没有任何干预措施被证明对感染SARS-CoV2的病例有效。综述了有关COVID-19感染的临床和实验室表现的现有知识，并结合了关于严重急性呼吸系统综合症冠状病毒（SARS-CoV1）和中东呼吸系统综合症（MERS）的免疫致病机制的知识，以阐明理论并提出可能的治疗干预措施。SARS-CoV2免疫致病机制从最初使病毒逃逸到过度炎症性免疫反应的免疫抑制机制有所不同。最终，治疗干预将取决于阶段。