Parasitic worms (helminths) developed various immunoregulatory mechanisms to counteract the immune system of their host. The increasing identification and characterization of helminth-derived factors with strong immune modulatory activity provides novel insights into immune escape strategies of helminths. Such factors might be good targets to enhance anti-helminthic immune responses. In addition, immunosuppressive helminth-derived factors could be useful to develop new therapeutic strategies for treatment of chronic inflammatory conditions. This review will take an in depth look at the effects of immunomodulatory molecules produced by different helminths with a focus on schistosomes and mouse models of hookworm infections.

寄生蠕虫（蠕虫）开发了各种免疫调节机制来抵消其宿主的免疫系统。具有强大的免疫调节活性的蠕虫衍生因子的不断鉴定和表征为蠕虫的免疫逃逸策略提供了新的见解。这些因素可能是增强抗蠕虫免疫反应的良好靶标。另外，免疫抑制性蠕虫来源的因子可能有助于开发治疗慢性炎症的新治疗策略。这篇综述将深入研究不同蠕虫产生的免疫调节分子的作用，重点是血吸虫和钩虫感染的小鼠模型。