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Self-assembling peptides: from a discovery in a yeast protein to diverse uses and beyond.
Protein Science ( IF 8 ) Pub Date : 2020-09-16 , DOI: 10.1002/pro.3951
Shuguang Zhang 1
Affiliation  

Well‐defined nanofiber scaffold hydrogels made of self‐assembling peptides have found their way into various 3D tissue culture and clinical products. I reflect initial puzzlement of the unexpected discovery, gradual understanding of how these peptides undergo self‐assembly, to eventually translating designer biological scaffolds into commercial products. Peptides are ubiquitous in nature and useful in many fields. They are found as hormones, pheromones, antibacterial, and antifungal agents in innate immunity systems, toxins, as well anti‐inset pesticides. However, the concept of peptides as materials was not recognized until 1990 when a self‐assembling peptide as a repeating segment in a yeast protein was serendipitously discovered. The peptide materials have bona fide materials properties and are made from simple amino acids with well‐ordered nanostructures under physiological conditions. Some current applications include: (a) Real 3D tissue cell cultures of diverse tissue cells and various stem cells; (b) reparative and regenerative medicine as well as tissue engineering; (c) 3D tissue printing; (d) sustained releases of small molecules, growth factors and monoclonal antibodies; and (e) accelerated wound healing of skin and diabetic ulcers as well as instant hemostasis in surgery. Self‐assembling peptide nanobiotechnology will likely continue to expand in many directions in the coming years. I will also briefly introduce my current research using a simple QTY code for membrane protein design. I am greatly honored and humbled to be invited to contribute an Award Winner Recollection of the 2020 Emil Thomas Kaiser Award from the Protein Society.

中文翻译:

自组装肽:从酵母蛋白的发现到多种用途等。

由自组装肽制成的定义明确的纳米纤维支架水凝胶已用于各种 3D 组织培养和临床产品。我反映了对意外发现的最初困惑,逐渐了解这些肽如何进行自组装,最终将设计的生物支架转化为商业产品。肽在自然界中无处不在,可用于许多领域。它们被发现作为先天免疫系统中的激素、信息素、抗菌剂和抗真菌剂、毒素以及抗虫害杀虫剂。然而,肽作为材料的概念直到 1990 年才被人们偶然发现作为酵母蛋白质中的重复片段的自组装肽被发现。肽材料具有真正的材料特性,在生理条件下由具有有序纳米结构的简单氨基酸制成。目前的一些应用包括: (a) 各种组织细胞和各种干细胞的真实 3D 组织细胞培养;(b) 修复和再生医学以及组织工程;(c) 3D 组织打印;(d) 小分子、生长因子和单克隆抗体的持续释放;(e) 加速皮肤和糖尿病溃疡的伤口愈合以及手术中的即时止血。自组装肽纳米生物技术在未来几年可能会继续向多个方向发展。我还将简要介绍我目前的研究,使用简单的 QTY 代码进行膜蛋白设计。
更新日期:2020-10-30
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