Chemical protein modifications facilitate the investigation of natural posttranslational protein modifications and allow the design of proteins with new functions. Proteins can be modified at a late stage on amino acid side chains by chemical methods. The indole moiety of tryptophan residues is an emerging target of such chemical modification strategies because of its unique reactivity and low abundance. This review provides an overview of the recently developed methods of tryptophan modification at the peptide and protein levels.

中文翻译：

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肽和蛋白质中色氨酸残基的化学修饰。

化学蛋白质修饰促进了天然翻译后蛋白质修饰的研究，并允许设计具有新功能的蛋白质。蛋白质可以通过化学方法在后期氨基酸侧链上进行修饰。由于其独特的反应性和低丰度，色氨酸残基的吲哚部分是此类化学修饰策略的新兴目标。本综述概述了最近开发的肽和蛋白质水平的色氨酸修饰方法。