A systematically chemical investigation of Citrus changshan‐huyou Y.B.Chang resulted in the isolation and structure determination of twelve known natural products, including limonoid, nootkatone, scoparone, β‐sitosterol, 3,3′,4′,5,6,7,8,‐heptamethoxyflavone, nobiletin, tangeretin, naringin, hesperidin, neohesperidin, 3,5‐dihydroxyphenyl β‐D‐glucoside, β‐sitosterol‐D‐glucoside. The structure modification of the most abundant compound limonin further led to eight limonoid derivatives, including epi‐limonol, epi‐limonyl acetate, and six new compounds epi‐limonol A, limonol A, limonol B, epi‐limonol B, epi‐limonol C, epi‐limonol D, which enlarged the chemical diversity of limonin related limonoids. The structures of the new limonoid derivatives were identified by extensive spectroscopic analysis. In bioassay, all the isolates, the semi‐synthetic derivatives and the previously isolated limonoids in our natural product library were subjected for anti‐inflammatory activities evaluation, and several limonoids exhibited the inhibition of TNF‐α release.

中文翻译：

---

柑橘常山-胡油YB Chang的化学成分及其抗炎活性

对柑橘常山-胡油 YBchang 进行系统化学研究，分离并确定了 12 种已知天然产物，包括柠檬苦素、nootkatone、scoparone、β-谷甾醇、3,3',4',5,6,7,8，七甲氧基黄酮、川陈皮素、橘皮苷、柚皮苷、橙皮苷、新橙皮苷、3,5-二羟基苯基β-D-葡萄糖苷、β-谷甾醇-D-葡萄糖苷。最丰富的化合物柠檬苦素的结构修饰进一步导致了八种柠檬苦素衍生物，包括表柠檬醇、表柠檬醇乙酸酯和六种新化合物表柠檬醇A、柠檬醇A、柠檬醇B、表柠檬醇B、表柠檬醇C ，epi-limonol D，扩大了柠檬苦素相关柠檬苦素的化学多样性。通过广泛的光谱分析鉴定了新的柠檬苦素衍生物的结构。在生物测定中，所有的分离株，