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A Step toward Molecular Evolution of RNA: Ribose Binds to Prebiotic Fatty Acid Membranes, and Nucleosides Bind Better than Individual Bases Do
ChemBioChem ( IF 3.2 ) Pub Date : 2020-09-17 , DOI: 10.1002/cbic.202000638
Mengjun Xue 1 , Roy A. Black 1 , Caitlin E. Cornell 1 , Gary P. Drobny 1 , Sarah L. Keller 1
Affiliation  

Membranes set the stage for RNA formation. RNA is a polymer of bases, sugar (ribose), and phosphate. Binding of these building blocks to prebiotic, fatty‐acid membranes may have facilitated RNA's formation. On their own, some bases bind weakly to membranes, whereas a base linked to ribose or phosphoribose binds more strongly. Thus, simple membranes could have selected and concentrated linked versions of RNA's building blocks prior to their polymerization. More information can be found in the communication by R. A. Black et al.
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中文翻译:

迈向RNA分子进化的一步:核糖与益生元脂肪酸膜结合,而核苷的结合优于单个碱基

膜为RNA的形成奠定了基础。RNA是碱基,糖(核糖)和磷酸盐的聚合物。这些构件与益生元脂肪酸膜的结合可能促进了RNA的形成。单独地,一些碱基与膜的结合较弱,而与核糖或磷酸核糖相连的碱基则结合更牢固。因此,简单的膜在聚合之前可能已经选择并浓缩了RNA结构单元的链接版本。可以在R. A. Black等人的来文中找到更多信息。
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更新日期:2020-10-02
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