This study investigates whether the circulating miR‐155, let‐7c, miR‐21, and PTEN levels to be used in the differential diagnosis of patients with idiopathic granulomatous mastitis (IGM) and breast cancer (BC). Forty‐five patients with BC, 50 patients with IGM, and 48 healthy volunteers were included in the study. Serum miR‐21 expression was significantly higher in BC (fold change = 2.42) and IGM group (fold change = 1.33) compared to control (p < .001). Serum miR‐155 and let‐7c expression levels were significantly lower in both groups compared to the control group (p < .001). miR‐21 expression in BC was significantly higher than IGM (fold change = 1.976; p < .001). PTEN levels in BC were significantly higher than IGM (p < .001) and significantly lower than the control group (p < .001); the IGM group was significantly lower than the control group (p < .001). In addition to radiological data, serum miR‐21 and PTEN levels may be noninvasive biomarkers that can help differentiate IGM from BC. The results of the study will lead to future studies in the differential diagnosis of IGM and BC.

中文翻译：

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循环 miR-155、let-7c、miR-21 和 PTEN 水平在特发性肉芽肿性乳腺炎和乳腺癌的鉴别诊断和预后中。

本研究调查循环 miR-155、let-7c、miR-21 和 PTEN 水平是否可用于特发性肉芽肿性乳腺炎 (IGM) 和乳腺癌 (BC) 患者的鉴别诊断。该研究包括 45 名 BC 患者、50 名 IGM 患者和 48 名健康志愿者。与对照组相比，BC（倍数变化 = 2.42）和 IGM 组（倍数变化 = 1.33）的血清 miR-21 表达显着更高（p  < .001）。与对照组相比，两组的血清 miR-155 和 let-7c 表达水平均显着降低（p  < .001）。BC 中 miR-21 的表达显着高于 IGM（倍数变化 = 1.976；p  < .001）。BC 中 PTEN 水平显着高于 IGM（p < .001) 且显着低于对照组 ( p  < .001)；IGM 组显着低于对照组 ( p  < .001)。除了放射学数据，血清 miR-21 和 PTEN 水平可能是有助于区分 IGM 和 BC 的无创生物标志物。该研究的结果将导致未来 IGM 和 BC 鉴别诊断的研究。