Even though medical devices have improved a lot over the past decades, there are still issues regarding their anti‐biofouling properties and tribological performance, and both aspects contribute to the short‐ and long‐term failure of these devices. Coating these devices with a biocompatible layer that reduces friction, wear, and biofouling at the same time would be a promising strategy to address these issues. Inspired by the adhesion mechanism employed by mussels, here, dopamine is made use of to immobilize lubricious mucin macromolecules onto both manufactured commercial materials and real medical devices. It is shown that purified mucins successfully adsorb onto a dopamine pre‐coated substrate, and that this double‐layer is stable toward mechanical challenges and storage in aqueous solutions. Moreover, the results indicate that the dopamine/mucin double‐layer decreases friction (especially in the boundary lubrication regime), reduces wear damage, and provides anti‐biofouling properties. The results obtained in this study show that such dopamine/mucin double‐layer coatings can be powerful candidates for improving the surface properties of medical devices such as catheters, stents, and blood vessel substitutes.

中文翻译：

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受生物启发的多巴胺/粘胶涂层可为医疗应用提供润滑性，耐磨性和抗细胞性

尽管医疗设备在过去几十年中已经取得了很大进步，但在其抗生物污垢特性和摩擦学性能方面仍然存在问题，并且这两个方面都导致了这些设备的短期和长期故障。同时在这些设备上涂上一层生物相容性涂层，以减少摩擦，磨损和生物污染，这将是解决这些问题的一种有前途的策略。受贻贝采用的粘附机制的启发，多巴胺可用于将润滑性粘蛋白大分子固定在制造的商业材料和实际医疗设备上。结果表明，纯化的粘蛋白可以成功地吸附到预涂多巴胺的基质上，并且该双层膜对机械挑战和在水溶液中的存储稳定。而且，结果表明，多巴胺/粘蛋白双层降低了摩擦力（尤其是在边界润滑状态下），减少了磨损，并提供了抗生物污垢特性。这项研究获得的结果表明，这种多巴胺/粘蛋白双层涂层可以作为改善医疗器械（如导管，支架和血管替代物）表面性能的有力候选者。