The emergence of luminescence nanothermometry in bio and nanomedicine has enabled achievements outside the reach of conventional techniques. For instance, it has provided real‐time monitoring of in vivo thermal therapies of tumors, a mandatory requirement for these techniques to work safely and efficiently. However, the reliability of intratumoral thermal readings is currently in question due to the presence of artefacts caused by the inhomogeneous optical properties of biological tissues. This work demonstrates how it is possible to avoid, under specific conditions, these artefacts and reach precise and reliable in vivo intratumoral thermal feedback during in vivo photothermal treatments. The method proposed is based on the use of luminescent nanoparticles capable of multiparametric thermal sensing. The results demonstrate how the convergence of the different thermal readouts becomes a solid indicator of their reliability. It is shown how this new approach makes possible precise (thermal uncertainties below 1 °C) intratumoral thermal feed‐back, while simple, efficient, and minimally invasive in vivo thermal treatments of surface tumors is carried out. Results included in this work provide an ingenious route toward the consolidation of luminescence nanothermometry as a convincing technique for high sensitivity preclinical thermal sensing, while also constituting a step toward improved photothermal therapies.

中文翻译：

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具有多参数感应的Ag2S纳米加热器在体内肿瘤治疗期间提供可靠的热反馈

生物和纳米医学中发光纳米温度计的出现使传统技术无法实现的成就成为可能。例如，它提供了对肿瘤体内热疗法的实时监控，这是这些技术安全有效地工作的强制性要求。然而，由于存在由生物组织的不均匀光学特性引起的伪像，因此目前对肿瘤内热读数的可靠性提出了质疑。这项工作演示了如何在特定条件下避免这些伪像，并在体内光热治疗过程中达到精确可靠的体内肿瘤内热反馈。提出的方法基于使用能够进行多参数热传感的发光纳米粒子。结果表明，不同热读数的收敛如何成为其可靠性的可靠指标。展示了这种新方法如何实现精确的（温度不确定性低于1°C）肿瘤内热反馈，同时对表面肿瘤进行了简单，有效且微创的体内热处理。这项工作中包含的结果为整合发光纳米温度计提供了一条巧妙的途径，这是一种用于高灵敏度临床前热感测的令人信服的技术，同时也构成了朝着改进光热疗法迈进的一步。并且对表面肿瘤进行了微创的体内热处理。这项工作中包含的结果为整合发光纳米温度计提供了一条巧妙的途径，这是一种用于高灵敏度临床前热感测的令人信服的技术，同时也构成了朝着改进光热疗法迈进的一步。并且对表面肿瘤进行了微创的体内热处理。这项工作中包含的结果为整合发光纳米温度计提供了一条巧妙的途径，这是一种用于高灵敏度临床前热感测的令人信服的技术，同时也构成了朝着改进光热疗法迈进的一步。