Wireless Programmable Recording and Stimulation of Deep Brain Activity in Freely Moving Humans.,Neuron

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Wireless Programmable Recording and Stimulation of Deep Brain Activity in Freely Moving Humans.
Neuron ( IF 16.2 ) Pub Date : 2020-09-17 , DOI: 10.1016/j.neuron.2020.08.021
Uros Topalovic ₁ , Zahra M Aghajan ₂ , Diane Villaroman ₃ , Sonja Hiller ₂ , Leonardo Christov-Moore ₂ , Tyler J Wishard ₂ , Matthias Stangl ₂ , Nicholas R Hasulak ₄ , Cory S Inman ₂ , Tony A Fields ₅ , Vikram R Rao ₆ , Dawn Eliashiv ₅ , Itzhak Fried ₇ , Nanthia Suthana ₈

Affiliation

Department of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90024, USA.
Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90024, USA.
Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
NeuroPace, Mountain View, CA 94043, USA.
Department of Neurology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Department of Neurology and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94143, USA.
Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90024, USA; Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Tel Aviv Sourasky Medical Center and Sackler Faculty School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90024, USA; Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Uncovering the neural mechanisms underlying human natural ambulatory behavior is a major challenge for neuroscience. Current commercially available implantable devices that allow for recording and stimulation of deep brain activity in humans can provide invaluable intrinsic brain signals but are not inherently designed for research and thus lack flexible control and integration with wearable sensors. We developed a mobile deep brain recording and stimulation (Mo-DBRS) platform that enables wireless and programmable intracranial electroencephalographic recording and electrical stimulation integrated and synchronized with virtual reality/augmented reality (VR/AR) and wearables capable of external measurements (e.g., motion capture, heart rate, skin conductance, respiration, eye tracking, and scalp EEG). When used in freely moving humans with implanted neural devices, this platform is adaptable to ecologically valid environments conducive to elucidating the neural mechanisms underlying naturalistic behaviors and to the development of viable therapies for neurologic and psychiatric disorders.

中文翻译：

自由移动人类大脑深部活动的无线可编程记录和刺激。

揭示人类自然走动行为背后的神经机制是神经科学的一项重大挑战。当前的商用可植入设备允许记录和刺激人类大脑深部活动，可以提供宝贵的内在大脑信号，但并非天生为研究而设计的，因此缺乏灵活的控制和与可穿戴传感器的集成。我们开发了一个移动深部脑记录和刺激 (Mo-DBRS) 平台，该平台可实现无线和可编程颅内脑电图记录和电刺激与虚拟现实/增强现实 (VR/AR) 和能够进行外部测量（例如，运动捕获、心率、皮肤电导、呼吸、眼动追踪和头皮 EEG）。

更新日期：2020-10-29

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