Recent work by Kadosh et al. (2020) suggests that mutant p53 activity in gut epithelia is influenced by local production of microbial metabolites. The switch of p53 from tumor suppressor to oncogene is location-dependent and is impacted by microbially derived gallic acid.

中文翻译：

---

肠道微生物对致癌驱动因素的影响：位置很重要。

Kadosh 等人最近的工作。(2020) 表明肠道上皮细胞中的突变 p53 活性受微生物代谢物的局部产生的影响。p53 从肿瘤抑制基因到癌基因的转换是位置依赖性的，并受微生物来源的没食子酸的影响。