A 63-day feeding trial was conducted to explore dietary yeast cell wall (YCW) on growth, immunity and disease resistance against Aeromonas hydrophila in gibel carp (Carassius auratus gibelio var. CAS Ⅲ) (initial body weight: 8.49 ± 0.27 g). Four isonitrogenous and isoenergetic diets were formulated to contain 0 % or 0.4 % three types of yeast cell wall (YCW) (termed as YCW0, YCW1, YCW2 or YCW3, respectively). Fish were randomly divided into 4 feeding groups in triplicates of 22 fish in each tank. Results showed that the highest final body weight was observed in fish fed YCW3 diet than the control (P < 0.05). Compared to the control group, significantly higher FE was found in groups of YCW2 and YCW3 (P < 0.05). There were no significant differences in feeding rate, specific growth rate, protein retention rate and energy retention rate among treatments (P > 0.05). Dietary supplementation of YCW decreased condition factor, hepatosomatic index and viscerosomatic index (P < 0.05). Dietary addition of YCW3 significantly increased serum complement C3 compared to control group (P < 0.05). The relative expression of complement C3 in liver was significantly upregulated in fish fed YCW3 supplemented diet (P < 0.05). Dietary YCW1 significantly increased lysozyme C mRNA level (P < 0.05). The relative expressions of TNF-α1 and IL-8 were not significantly affected by YCW inclusion in the diet (P > 0.05). Hepatic IL-1β and TGF-β expressions were significantly down-regulated in the fish fed YCWs (P < 0.05). Furthermore, dietary administration of YCW1 and YCW3 could to some extent improve disease resistance against bacterial challenge. Based on growth performance and immunity, 0.4 % YCW3 was recommended in the gibel carp diet.

进行了为期63天的饲养试验，以研究饮食酵母细胞壁（YCW）对长鳍鲤（Carassius auratus gibelio var。CASⅢ ）（初始体重：8.49±0.27 g）的生长，免疫力和抗亲水性气单胞菌的抗病性。配制了四种等氮和等能饮食，分别含有0％或0.4％的三种类型的酵母细胞壁（YCW）（分别称为YCW0，YCW1，YCW2或YCW3）。将鱼随机分为4个饲养组，一式三份，每个槽中有22条鱼。结果表明，饲喂YCW3日粮的鱼类的最高最终体重高于对照组（P  <0.05）。与对照组相比，YCW2和YCW3组的FE显着更高（P<0.05）。各处理之间的摄食率，比生长率，蛋白质保留率和能量保留率无显着差异（P  > 0.05）。日粮中添加YCW降低了病因，肝体指数和内脏指数（P <0.05）。与对照组相比，饮食中添加YCW3可以显着增加血清补体C3（P <0.05）。补充YCW3的鱼饲料中肝脏补体C3的相对表达显着上调（P  <0.05）。饮食YCW1显着提高了溶菌酶C mRNA水平（P  <0.05）。饮食中添加YCW对TNF-α1和IL-8的相对表达无明显影响（P > 0.05）。喂鱼的YCWs中肝IL-1β和TGF-β的表达显着下调（P  <0.05）。此外，饮食中施用YCW1和YCW3可以在某种程度上改善抗细菌攻击的疾病抵抗力。基于生长性能和免疫力，建议在长鳍鲤鱼日粮中添加0.4％的YCW3。