Osteoarthritis (OA) is a progressive degenerative disease that affects all synovial joints, causing the disability of the main locomotor diarthrodial joints. OA pathogenesis is caused by a complex interplay between a number of genetic and environmental risk factors, involved in the early onset and progression of this chronic inflammatory joint disease. Uncovering the underlying immunological and genetic mechanisms will enable an insight into OA pathophysiology and lead to novel and integrative approaches in the treatment of OA patients, together with a reduction of the disease risk, or a delay of its onset in susceptible patients.

中文翻译：

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深入了解骨关节炎易感性：免疫学和遗传背景的整合。

骨关节炎（OA）是一种进行性退行性疾病，影响所有滑膜关节，导致主要运动关节功能障碍。OA 发病机制是由许多遗传和环境危险因素之间复杂的相互作用引起的，参与这种慢性炎症性关节疾病的早期发病和进展。揭示潜在的免疫学和遗传机制将有助于深入了解 OA 病理生理学，并为治疗 OA 患者带来新颖的综合方法，同时降低易感患者的疾病风险或延迟其发病。