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Identification of putative calorie restriction mimetics using mammalian gene expression profiles.
Open Biology ( IF 5.8 ) Pub Date : 2020-09-16 , DOI: 10.1098/rsob.200158
Alexei Vazquez 1, 2
Affiliation  

Obesity is a risk factor for cardiovascular diseases, diabetes and cancer. In theory, the obesity problem could be solved by the adherence to a calorie-restricted diet, but that is not generally achieved in practice. An alternative is a pharmacological approach, using compounds that trigger the same metabolic changes associated with calorie restriction. Here, I expand in the pharmacological direction by identifying compounds that induce liver gene signature profiles that mimic those induced by calorie restriction. Using gene expression profiles from mice and rat, I identify corticosteroids, PPAR agonists and some antibacterial/antifungal as candidate compounds mimicking the response to calorie restriction in the liver gene signatures.



中文翻译:

使用哺乳动物基因表达谱鉴定推定的卡路里限制模拟物。

肥胖是心血管疾病、糖尿病和癌症的危险因素。理论上,肥胖问题可以通过坚持限制卡路里的饮食来解决,但这在实践中通常无法实现。另一种选择是药理学方法,使用可触发与卡路里限制相关的相同代谢变化的化合物。在这里,我通过鉴定诱导肝脏基因特征谱的化合物来扩展药理学方向,这些化合物模拟由卡路里限制引起的那些。使用小鼠和大鼠的基因表达谱,我确定皮质类固醇、PPAR 激动剂和一些抗菌/抗真菌剂作为候选化合物,模拟肝脏基因特征中对卡路里限制的反应。

更新日期:2020-09-16
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