Asthma is a chronic inflammatory disease associated with airway hyper-responsiveness, chronic inflammatory response, and excessive structural remodeling. The current therapeutic strategies in asthmatic patients are based on controlling the activity of type 2 T helper lymphocytes in the pulmonary tissue. However, most of the available therapies are symptomatic and expensive and with diverse side outcomes in which the interruption of these modalities contributes to the relapse of asthmatic symptoms. Up to date, different reports highlighted the advantages and beneficial outcomes regarding the transplantation of different stem cell sources, and relevant products from for the diseases’ alleviation and restoration of injured sites. However, efforts to better understand by which these cells elicit therapeutic effects are already underway. The precise understanding of these mechanisms will help us to translate stem cells into the clinical setting. In this review article, we described current knowledge and future perspectives related to the therapeutic application of stem cell-based therapy in animal models of asthma, with emphasis on the underlying therapeutic mechanisms.

中文翻译：

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阐明间充质干细胞在哮喘中的治疗作用。

哮喘是一种慢性炎性疾病，与气道高反应性，慢性炎性反应和过度的结构重塑有关。哮喘患者的当前治疗策略是基于控制肺组织中2型T辅助淋巴细胞的活性。然而，大多数可用的疗法是对症的和昂贵的，并且具有多种副作用，其中这些方式的中断导致哮喘症状的复发。迄今为止，不同的报告都强调了在移植不同干细胞来源以及相关产品以减轻疾病和修复受伤部位方面的优势和有益结果。但是，已经在努力更好地了解这些细胞通过何种方式引起治疗效果。对这些机制的精确理解将有助于我们将干细胞转化为临床环境。在这篇综述文章中，我们描述了与基于干细胞的疗法在哮喘动物模型中的治疗应用有关的当前知识和未来观点，重点在于潜在的治疗机制。