To investigate the dynamic change of lipid profile under double filtration plasmapheresis (DFPP) in severe hypertriglyceridemia-induced acute pancreatitis (sHTGP) patients and ascertain the association between these changes and the clinical prognosis. sHTGP patients admitted within 72 h after disease onset were included, and all the patients received DFPP within 24 h after admission. Lipid profile were detected on admission, consecutive 4 days after DFPP and at discharge. There were 47 sHTGP patients enrolled in this study. At admission, all the parameters of lipid profile changed significantly except for low density lipoprotein. In the first day after DFPP, the serum level of TG, cholesterol and very low density lipoprotein declined significantly, while the high-density lipoprotein (HDL) as well as apoprotein A1 elevated obviously (P < 0.05). TG maintained the downward trend in the following three days and the other parameters kept steady. Linear regression analysis showed that HDL was negatively correlated with the duration of hospitalization among three adjusted models (P = 0.043, P = 0.029, P = 0.025 respectively). There was distinct fluctuation of the lipid profile upon the burst of sHTGP and the parameters changed significantly in the first day after DFPP. Among these parameters, HDL may serve as a biomarker for disease prognosis in patients with sHTGP.

中文翻译：

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双重滤过血浆置换术对严重高甘油三酯血症引起的急性胰腺炎患者血脂谱的动态变化：一项回顾性观察研究。

目的探讨重度高甘油三酯血症诱发的急性胰腺炎（sHTGP）患者在双重滤过血浆置换术（DFPP）下血脂谱的动态变化，并确定这些变化与临床预后之间的关系。包括发病后72小时内入院的sHTGP患者，所有患者入院后24小时内接受DFPP治疗。入院时，DFPP后连续4天和出院时均检测到脂质分布。本研究纳入了47位sHTGP患者。入院时，除低密度脂蛋白外，所有脂质谱参数均发生显着变化。DFPP后的第一天，血清TG，胆固醇和极低密度脂蛋白水平显着下降，而高密度脂蛋白（HDL）和载脂蛋白A1则明显升高（P <0.05）。TG在随后的三天内保持下降趋势，其他参数保持稳定。线性回归分析显示，在三种调整后的模型中，HDL与住院时间呈负相关（分别为P = 0.043，P = 0.029，P = 0.025）。sHTGP爆发后，脂质谱存在明显的波动，并且在DFPP后的第一天参数发生了显着变化。在这些参数中，HDL可以作为sHTGP患者疾病预后的生物标志物。sHTGP爆发后，脂质谱存在明显的波动，并且在DFPP后的第一天参数发生了显着变化。在这些参数中，HDL可以作为sHTGP患者疾病预后的生物标志物。sHTGP爆发后，脂质谱存在明显的波动，并且在DFPP后的第一天参数发生了显着变化。在这些参数中，HDL可以作为sHTGP患者疾病预后的生物标志物。