The use of plant extracts is a low-cost and green way to synthesize nanoparticles. In this research, the authors investigated the antibacterial, cytotoxic and antiangiogenic properties of silver nanoparticles (AgNPs) synthesized using Amaranthus cruentus extract. The fabricated nanoparticles were characterized by transmission electron microscopy (TEM), field-emission scanning electron microscopy, Fourier transform infrared spectroscopy, dynamic light scattering and X-ray diffraction. The TEM results showed that the typical size of the AgNPs recorded was 15 nm. Biological tests indicated that the biosynthesized AgNPs had caused a decrease in cancerous cells (MCF-7) and had a high antibacterial activity against Escherichia coli, Staphylococcus epidermidis and Staphylococcus aureus. According to data analysis, the number and length of the blood vessels in different concentrations of AgNPs reduced significantly (depending on the dose). The chorioallantoic membrane assay revealed a large decrease in the number and length of angiogenic blood vessels in the presence of AgNPs. Real-time polymerase chain reaction and flow cytometry studies showed a dramatic increase in the gene expression of caspase-3 and caspase-8.

中文翻译：

---

A菜生物合成的银纳米颗粒的表征

植物提取物的使用是一种低成本且绿色的合成纳米颗粒的方法。在这项研究中，作者研究了使用A菜提取物合成的银纳米颗粒（AgNPs）的抗菌，细胞毒性和抗血管生成特性。通过透射电子显微镜（TEM），场发射扫描电子显微镜，傅立叶变换红外光谱，动态光散射和X射线衍射对制备的纳米颗粒进行表征。TEM结果表明，记录的AgNP的典型尺寸为15nm。生物学测试表明，生物合成的AgNPs导致癌细胞（MCF-7）减少，并对大肠杆菌，表皮葡萄球菌和表皮葡萄球菌具有很高的抗菌活性。金黄色葡萄球菌。根据数据分析，不同浓度的AgNPs的血管数量和长度显着减少（取决于剂量）。绒毛膜尿囊膜测定显示在存在AgNP的情况下，血管生成血管的数目和长度大大减少。实时聚合酶链反应和流式细胞术研究表明caspase-3和caspase-8的基因表达显着增加。