The raft is an emerging drug delivery system that not only provides rapid relief from reflux disorders, but also sustains drug release. The objective of this work was to develop and characterize raft-forming bilayer tablets in which pantoprazole sodium sesquihydrate (PSS) was targeted at sustained release and domperidone maleate (DM) was used to obtain an immediate-release effect and perform pharmacokinetic studies. Tablets were prepared using the wet granulation method. Rafts were characterized in terms of strength, weight, volume, resilience, acid-neutralizing capacity, floating lag time and total floating time. Dissolution studies were performed using simulated gastric fluid with pH 1·2. Compatibility were performed by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction and differential scanning calorimetry (DSC). Percentage release of the optimized R7 formulation was 94% for PSS and 98% for DM. First-order release kinetics were followed and a non-Fickian diffusion was observed; the value of n was greater than 0·7 in the Korsmeyer–Peppas model. FTIR and DSC studies showed chemical and thermal stability between the drug and polymers. C _max values of the test and reference formulations of PSS were 46·080 ± 0·567, 46·350 ± 0·507 and DM were 14·090 ± 1·678 and 10·560 ± 1·098 μg/ml, respectively.

中文翻译：

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pan托拉唑和多潘立酮递送的筏形成系统：体外和体内研究

木排是一种新兴的药物输送系统，不仅可以快速缓解回流障碍，而且还可以维持药物释放。这项工作的目的是开发和表征筏形成双层片剂，其中泛托拉唑倍半水合物（PSS）靶向缓释，而马来酸多潘立酮（DM）用于获得速释效果并进行药代动力学研究。使用湿法制粒法制备片剂。用强度，重量，体积，回弹性，酸中和能力，漂浮滞后时间和总漂浮时间来表征筏。使用pH 1·2的模拟胃液进行溶出度研究。通过傅里叶变换红外光谱（FTIR），X射线衍射和差示扫描量热法（DSC）进行兼容性。对于PSS，最佳R7配方的释放百分比为94％，对于DM，则为98％。遵循一级释放动力学，观察到非菲克扩散。的价值在Korsmeyer-Peppas模型中，n大于0·7。FTIR和DSC研究表明，药物与聚合物之间具有化学和热稳定性。PSS的测试和参考制剂的C _最大值分别为46·080±0·567、46·350±0·507和DM为14·090±1·678和10·560±1·098μg/ ml 。