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ANNALS EXPRESS: Prognostic value of serum Aquaporin-1, Aquaporin-3, and Galectin-3 for young patients with colon cancer.
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine ( IF 2.2 ) Pub Date : 2020-09-16 , DOI: 10.1177/0004563220961752
Yanyan Hong 1 , Zhendong Chen 1 , Na Li 1 , Mingjun Zhang 1
Affiliation  

Background: This study aimed to investigate the long-term prognosis value of serum Galectin-3, aquaporin (AQP)-1 and AQP-3 in young patients with colon cancer. Methods: A total of 100 young patients with colon cancer, 100 cases of benign colon, and 100 healthy people were collected. All colon cancer patients were followed up for 42 months. Results: Compared with the benign lesion group and the control group, preoperative serum Galectin-3, AQP-1, and AQP-3 levels were significantly increased in patients with colon cancer (P<0.05). The immunohistochemistry scores of Galectin-3, AQP-1, and AQP-3 in colon cancer patients were positively correlated with serum Galectin-3, AQP-1, and AQP-3 levels (P<0.05). Serum Galectin-3, AQP-1, and AQP-3 levels were positively correlated with TNM staging (Galectin-3: rPearson=0.502, P<0.001; AQP-1: rPearson=0.415, P<0.001; AQP-3: rPearson=0.454, P<0.001), and differentiation (Galectin-3: rPearson=0.377, P=0.004; AQP-1: rPearson=0.411, P=0.001; AQP-3: rPearson=0.483, P<0.001). Receiver operator characteristic curve (ROC) analysis showed that the area under ROC curve (AUC) of the combination of Galectin-3, AQP-1, and AQP-3 in distinguishing colon cancer was 0.907. The sensitivity in the parallel mode was 87.6%, and the specificity in the serial mode was 98.2%. Compared with the low Galectin-3 group, low AQP-1 group and low AQP-3 group, the survival time of patients in the high Galectin-3 group (χ2=13.929, P<0.001), high AQP-1 group (χ2=10.157, P=0.001) and high AQP-3 group (χ2=4.364, P=0.037) were significantly shortened. Conclusion: Galectin-3 combined with AQP-1 and AQP-3 had important value in the identification of young patients with colon cancer and was of great value in evaluating long-term prognosis.



中文翻译:

ANNALS EXPRESS:血清Aquaporin-1,Aquaporin-3和Galectin-3对年轻结肠癌患者的预后价值。

背景:本研究旨在探讨血清Galectin-3,水通道蛋白(AQP)-1和AQP-3在年轻结肠癌患者中的长期预后价值。方法:收集了100例年轻的结肠癌患者,100例良性结肠癌和100例健康人。所有结肠癌患者均获随访42个月。结果:与良性病变组和对照组相比,结肠癌患者术前血清Galectin-3,AQP-1和AQP-3水平显着升高(P <0.05)。Galectin-3,AQP-1和AQP-3在结肠癌患者中的免疫组织化学评分与血清Galectin-3,AQP-1和AQP-3水平呈正相关(P <0.05)。血清Galectin-3,AQP-1和AQP-3水平与TNM分期呈正相关(Galectin-3:rPearson = 0.502,P <0.001; AQP-1:rPearson = 0。415,P <0.001;AQP-3:rPearson = 0.454,​​P <0.001)和分化(Galectin-3:rPearson = 0.377,P = 0.004; AQP-1:rPearson = 0.411,P = 0.001; AQP-3:rPearson = 0.483,P < 0.001)。接收者操作者特征曲线(ROC)分析显示,加勒汀3,AQP-1和AQP-3组合用于区分结肠癌的ROC曲线下面积(AUC)为0.907。并行模式下的灵敏度为87.6%,串行模式下的特异性为98.2%。与低Galectin-3组,低AQP-1组和低AQP-3组相比,高Galectin-3组(χ2= 13.929,P <0.001),高AQP-1组(χ2)的患者生存时间= 10.157,P = 0.001)和高AQP-3组(χ2= 4.364,P = 0.037)显着缩短。结论:

更新日期:2020-09-16
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