According to the 2020 Metrics of the HUPO Human Proteome Project (HPP), expression has now been detected at the protein level for >90% of the 19 773 predicted proteins coded in the human genome. The HPP annually reports on progress made throughout the world toward credibly identifying and characterizing the complete human protein parts list and promoting proteomics as an integral part of multiomics studies in medicine and the life sciences. NeXtProt release 2020–01 classified 17 874 proteins as PE1, having strong protein-level evidence, up 180 from 17 694 one year earlier. These represent 90.4% of the 19 773 predicted coding genes (all PE1,2,3,4 proteins in neXtProt). Conversely, the number of neXtProt PE2,3,4 proteins, termed the “missing proteins” (MPs), was reduced by 230 from 2129 to 1899 since the neXtProt 2019–01 release. PeptideAtlas is the primary source of uniform reanalysis of raw mass spectrometry data for neXtProt, supplemented this year with extensive data from MassIVE. PeptideAtlas 2020–01 added 362 canonical proteins between 2019 and 2020 and MassIVE contributed 84 more, many of which converted PE1 entries based on non-MS evidence to the MS-based subgroup. The 19 Biology and Disease-driven B/D-HPP teams continue to pursue the identification of driver proteins that underlie disease states, the characterization of regulatory mechanisms controlling the functions of these proteins, their proteoforms, and their interactions, and the progression of transitions from correlation to coexpression to causal networks after system perturbations. And the Human Protein Atlas published Blood, Brain, and Metabolic Atlases.

中文翻译：

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人类蛋白质组研究达到了一个重要里程碑：根据 HUPO 人类蛋白质组项目，目前预测的人类蛋白质的 90% 以上已得到可靠检测。

根据 HUPO 人类蛋白质组计划 (HPP) 的 2020 年指标，在人类基因组中编码的 19 773 种预测蛋白质中，目前已在蛋白质水平检测到超过 90% 的表达。HPP 每年报告世界各地在可靠地识别和表征完整的人类蛋白质部分列表以及促进蛋白质组学作为医学和生命科学多组学研究的一个组成部分方面所取得的进展。NeXtProt 2020-01 版本将 17 874 个蛋白质分类为 PE1，具有强有力的蛋白质水平证据，比一年前的 17 694 个增加了 180 个。这些代表了 19 773 个预测编码基因的 90.4%（neXtProt 中的所有 PE1,2,3,4 蛋白）。相反，自 neXtProt 2019-01 发布以来，neXtProt PE2,3,4 蛋白（称为“缺失蛋白”（MP））的数量从 2129 年到 1899 年减少了 230 个。PeptideAtlas 是 neXtProt 原始质谱数据统一再分析的主要来源，今年又补充了来自 MassIVE 的大量数据。PeptideAtlas 2020-01 在 2019 年至 2020 年间添加了 362 个典型蛋白质，MassIVE 又贡献了 84 个，其中许多将基于非 MS 证据的 PE1 条目转换为基于 MS 的亚组。19 个生物学和疾病驱动的 B/D-HPP 团队继续致力于识别疾病状态下的驱动蛋白、控制这些蛋白功能的调节机制、它们的蛋白质形式、它们的相互作用以及转变的进展从相关性到共表达，再到系统扰动后的因果网络。人类蛋白质图谱出版了血液、大脑和代谢图谱。