Repeated column chromatography of Syringa dilatata flowers, a native shrub to Korea, led to the isolation of eight new oleoside-type secoiridoids, syringoleosides A–H (1–8), as well as five known secoiridoids (9–13). The new chemical structures were identified through spectroscopic data analysis, as well as the application of chemical methods. Compounds 1, 2, 6, 7, 11, and 13 showed suppression effects on NO production in LPS-induced RAW 264.7 cells, with IC₅₀ values ranging from 32.5 ± 9.8 to 65.7 ± 11.0 μM, and no visible toxicity. The content of the major secoiridoids in S. dilatata flowers, compounds 1, 4, 5, 8, 9, 12, and 13, were determined through HPLC analysis.

中文翻译：

---

Syringoleosides AH、来自丁香花的 Secoiridoids 及其对 LPS 诱导的 RAW 264.7 细胞中 NO 产生的抑制。

的重复柱色谱法丁香dilatata花朵，天然灌木到韩国，导致了八个新木犀型secoiridoids隔离，syringoleosides A-H（1 - 8），以及5个已知secoiridoids（9 - 13）。通过光谱数据分析以及化学方法的应用，鉴定了新的化学结构。化合物1，2，6，7，11，和13中对NO生产呈现抑制效果LPS诱导RAW264.7细胞，用IC _50个值范围为32.5±9.8 65.7±11.0 μM，且无可见毒性。在各大secoiridoids的内容S. dilatata花朵，化合物1，4，5，8，9，12，和13，分别通过HPLC分析测定。