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Myeloid Differentiation Primary Response Protein 88 (MyD88): the central hub of TLR/IL-1R signaling.
Journal of Medicinal Chemistry ( IF 7.3 ) Pub Date : 2020-09-15 , DOI: 10.1021/acs.jmedchem.0c00884
Lingfeng Chen 1, 2, 3 , Lulu Zheng 4 , Pengqin Chen 1 , Guang Liang 1, 3
Affiliation  

Myeloid differentiation primary response protein 88 (MyD88) is a ubiquitously expressed cytoplasmic adaptor protein that plays a central role in the Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) signaling pathways. TLR/IL-1R pathways regulate the proliferation and differentiation of cells involved in the innate and adaptive immunity. Although the general TLR/IL-1R activation cascade is well understood, the molecular mechanisms involving MyD88 have only begun to surface in the past decade. In this review, we explore MyD88 structural biology, the role of posttranslational modifications (PTMs), and the recent developments in MyD88 inhibitor discovery and use. We also highlight the potential application of MyD88-targeted therapies in human diseases.

中文翻译:

骨髓分化主要反应蛋白88(MyD88):TLR / IL-1R信号传导的中心枢纽。

髓样分化初级应答蛋白88(MyD88)是一种普遍表达的胞质衔接蛋白,在Toll样受体(TLR)和白介素1受体(IL-1R)信号传导途径中起着核心作用。TLR / IL-1R通路调节与先天和适应性免疫有关的细胞的增殖和分化。尽管一般的TLR / IL-1R激活级联已广为人知,但涉及MyD88的分子机制只是在过去十年才开始浮出水面。在这篇综述中,我们探讨了MyD88结构生物学,翻译后修饰(PTM)的作用以及MyD88抑制剂发现和使用的最新发展。我们还强调了针对MyD88的疗法在人类疾病中的潜在应用。
更新日期:2020-09-15
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