Abstract

Resting-state fluctuations are ubiquitous and widely studied phenomena of the human brain, yet we are largely in the dark regarding their function in human cognition. Here we examined the hypothesis that resting-state fluctuations underlie the generation of free and creative human behaviors. In our experiment, participants were asked to perform three voluntary verbal tasks: a verbal fluency task, a verbal creativity task, and a divergent thinking task, during functional magnetic resonance imaging scanning. Blood oxygenation level dependent (BOLD)-activity during these tasks was contrasted with a control- deterministic verbal task, in which the behavior was fully determined by external stimuli. Our results reveal that all voluntary verbal-generation responses displayed a gradual anticipatory buildup that preceded the deterministic control-related responses. Critically, the time–frequency dynamics of these anticipatory buildups were significantly correlated with resting-state fluctuations’ dynamics. These correlations were not a general BOLD-related or verbal-response related result, as they were not found during the externally determined verbal control condition. Furthermore, they were located in brain regions known to be involved in language production, specifically the left inferior frontal gyrus. These results suggest a common function of resting-state fluctuations as the neural mechanism underlying the generation of free and creative behaviors in the human cortex.

中文翻译：

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静息状态波动是人脑中自由和创造性语言行为的基础。

摘要

静息状态波动是人类大脑中普遍存在且被广泛研究的现象，但我们在很大程度上对其在人类认知中的功能一无所知。在这里，我们研究了静息状态波动是产生自由和创造性人类行为的基础的假设。在我们的实验中，参与者被要求在功能性磁共振成像扫描期间执行三项自愿的口头任务：口头流畅性任务、口头创造力任务和发散思维任务。这些任务期间的血氧水平依赖性 (BOLD) 活动与控制确定性语言任务形成对比，其中行为完全由外部刺激决定。我们的结果表明，所有自愿的口头生成反应都显示出在确定性控制相关反应之前的逐渐预期积累。至关重要的是，这些预期积累的时频动态与静息状态波动的动态显着相关。这些相关性不是一般的 BOLD 相关或言语反应相关的结果，因为在外部确定的言语控制条件下没有发现它们。此外，它们位于已知参与语言产生的大脑区域，特别是左侧额下回。这些结果表明静息状态波动的共同功能是人类皮层中产生自由和创造性行为的神经机制。这些预期积累的时频动态与静息状态波动的动态显着相关。这些相关性不是一般的 BOLD 相关或言语反应相关的结果，因为在外部确定的言语控制条件下没有发现它们。此外，它们位于已知参与语言产生的大脑区域，特别是左侧额下回。这些结果表明静息状态波动的共同功能是人类皮层中产生自由和创造性行为的神经机制。这些预期积累的时频动态与静息状态波动的动态显着相关。这些相关性不是一般的 BOLD 相关或言语反应相关的结果，因为在外部确定的言语控制条件下没有发现它们。此外，它们位于已知参与语言产生的大脑区域，特别是左侧额下回。这些结果表明静息状态波动的共同功能是人类皮层中产生自由和创造性行为的神经机制。此外，它们位于已知参与语言产生的大脑区域，特别是左侧额下回。这些结果表明静息状态波动的共同功能是人类皮层中产生自由和创造性行为的神经机制。此外，它们位于已知参与语言产生的大脑区域，特别是左侧额下回。这些结果表明静息状态波动的共同功能是人类皮层中产生自由和创造性行为的神经机制。